Effects of a caloric restriction weight loss diet on tryptophan metabolism and inflammatory biomarkers in overweight adults

Autor: Ken Berger, Barbara Strasser, Dietmar Fuchs
Rok vydání: 2014
Předmět:
Zdroj: European Journal of Nutrition. 54:101-107
ISSN: 1436-6215
1436-6207
DOI: 10.1007/s00394-014-0690-3
Popis: Recent data suggest that chronic low-grade inflammation, a characteristic of obesity, is associated with altered tryptophan (Trp) and tyrosine (Tyr) metabolism and plays a role in neuropsychiatric symptoms. The present study assessed the effect of an extreme short-term diet on Trp breakdown and inflammatory biomarkers in overweight adults. Thirty-eight overweight participants (16 women, 22 men; average body mass index: 29 kg/m2, mean age 52.8 years) were randomized into two diet groups: a very low kcal diet group (VLCD; O 600 kcal/day, n = 21) and a low kcal diet group (LCD; O 1,200 kcal/day, n = 17). Assays included the measurement of Trp, kynurenine (Kyn), and their ratio, neopterin, phenylalanine (Phe), Tyr, as biologic markers; leptin, plasma insulin, glucose, and homeostatic model assessment-insulin resistance; and interleukin 6, tumor necrosis factor alpha, and C-reactive protein, as biochemical and inflammatory markers at baseline and after 2 weeks of treatment. Weight loss diet lowered leptin levels in both groups by 46 %, although not reaching significance. Trp and Kyn decreased significantly by 21 and 16 % for VLCD and by 15 and 17 % for the LCD group, respectively. A significant reduction in Phe was only seen after VLCD. Inflammatory biomarkers, neopterin, and Tyr were not significantly altered during the study period. Leptin was significantly correlated with Trp breakdown before and after the intervention (P
Databáze: OpenAIRE
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