| Autor: |
A. V. S. Himabindu*, M. Manasa, N. Neeraja, M. J. L. Manasa Reddy, B. Umadevi, S. Umamaheswari, K. Padmalatha |
| Rok vydání: |
2021 |
| DOI: |
10.5281/zenodo.5095047 |
| Popis: |
The main aim of the present work was to formulate and characterize oral sustained release mucoadhesive microspheres of Vildagliptin. Vildagliptin is a dipeptidyl peptidase IV (DPP-IV) inhibitors used in the management of diabetes. This drug also undergoes first-pass metabolism. To overcome this problem Vildagliptin mucoadhesive microspheres were developed to control the release rate of the drug and target to the specific site of the body to make an enormous impact in the formulation and development of novel drug delivery system and also improve efficient absorption and enhances oral bioavailbility of the drug due to high surface to volume ratio. It also provides an intimate contact of the drug delivery system to the absorbing mucous membrane for sustaining the drug action. This is a new oral drug delivery system which was developed and utilized both the concepts of sustained release and mucoadhesiveness in order obtain a unique drug delivery system which could remain in intestine and control the drug release for longer period of time. Key words: mucoadhesive, bioavailability, sustained release |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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