Biodegradation of a poly(alpha-amino acid) hydrogel. I. In vivo
| Autor: | D. F. Gibbons, James M. Anderson, A. Hiltner, H. R. Dickinson |
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| Rok vydání: | 1981 |
| Předmět: |
Male
Materials science Biomedical Engineering Biocompatible Materials macromolecular substances Biomaterials Hydrolysis In vivo Organic chemistry Animals Peritoneal Cavity chemistry.chemical_classification Swelling ratio Chromatography technology industry and agriculture Proteolytic enzymes Rats Inbred Strains Prostheses and Implants Biodegradation Amino acid Rats Biodegradation Environmental chemistry Subcutaneous implantation Degradation (geology) Peptides |
| Zdroj: | Journal of biomedical materials research. 15(4) |
| ISSN: | 0021-9304 |
| Popis: | A new hydrogel material has been prepared by crosslinking a hydrophilic, nonionic poly(amino acid), poly(2-hydroxyethyl-L-glutamine). The material properties of the hydrogel can be controlled by variation in the crosslink density, and the swelling ratio was found to be a sensitive and convenient method for measuring the extent of in vivo biodegradation of implanted specimens. Degradation of the material was observed only during the first 2 weeks of subcutaneous implantation in rats, and is attributed to hydrolysis by proteolytic enzymes released during the acute and chronic stages of the normal inflammatory response. |
| Databáze: | OpenAIRE |
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