Resorption rate, route of elimination, and ultrastructure of the implant site of polylactic acid in the abdominal wall of the rat

Autor: John M. Brady, Ervin E. Hunsuck, Duane E. Cutright, Gino C. Battistone, Robert A. Miller
Rok vydání: 1973
Předmět:
Zdroj: Journal of Biomedical Materials Research. 7:155-166
ISSN: 1097-4636
0021-9304
DOI: 10.1002/jbm.820070204
Popis: This experiment describes resorption rate, light and electron microscopic appearance of the implant site, and tissue distribution and route of elimination of radioactivity from carbon-labelled polylactic acid implants. Fifty-six rats received abdominal implants and were serially sacrificed at 28, 56, 84, 112, 140, 154, and 168 days. Urine and fecal output was measured for radioactivity, along with implant site and several tissues at the time of sacrifice. Tissue distribution of activity was negligible. Resorption rate of the implant was linear with 63.2% remaining after 168 days. Elimination of radioactivity was via respiration, approximately 29.4% by this route. Histologically, the implant was invaded rapidly along septal defects or slowly on broad fronts. Invading cells were characterized either by large double-walled vacuoles or by large accumulations of mitochondria and microvesicles adjacent to the implant surface. The long duration of this type of implant may be an important consideration in surgical applications.
Databáze: OpenAIRE