How safe are organs from deceased donors with neoplasia? The results of the Italian Transplantation Network
| Autor: | Desley Neil, Antonia D'Errico, Alessandro Nanni Costa, Umberto Montin, Amedeo Carraro, Aldo Scarpa, Giovanni Valotto, Ilaria Girolami, Francesca Puoti, Gianluigi Zaza, Luca Cima, Albino Eccher, Luca Novelli, Letizia Lombardini, Matteo Brunelli, Giovanni Gambaro |
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| Přispěvatelé: | Eccher A., Lombardini L., Girolami I., Puoti F., Zaza G., Gambaro G., Carraro A., Valotto G., Cima L., Novelli L., Neil D., Montin U., Scarpa A., Brunelli M., Nanni Costa A., D'Errico A. |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Adult
Male Pediatrics medicine.medical_specialty Time Factors Adolescent 030232 urology & nephrology 030204 cardiovascular system & hematology Malignancy Donor Selection 03 medical and health sciences Patient safety Young Adult 0302 clinical medicine Risk Factors Neoplasms medicine Humans Donor evaluation Donor with malignancy Neoplastic transmission Risk assessment Transplantation Young adult Child Aged Retrospective Studies Aged 80 and over Donor selection business.industry Retrospective cohort study Organ Transplantation Middle Aged medicine.disease Tissue Donors Treatment Outcome Italy Nephrology Donation Child Preschool Female Patient Safety business |
| Popis: | Guidelines for donor selection have changed to expand the donor pool, considering potential donors affected by a neoplasm. Aim of this retrospective study is to look at the use of organs from donors with a current or history of neoplasm within the Italian Transplant Network. Data, collected and validated by Italian National Health Institute for the time interval 2006–2015, have been reviewed retrospectively by mean of multivariable pivot tables. Donors with neoplasia represented about 5% of all donors, resulting in about 4% of all transplants. Donors presented a benign neoplasm in 29.08% of cases, a malignancy with variable risk of transmission in 69.75% while in 1.34% the nature of neoplasm could not be assessed. Considering all procedures, rate of transmission of a malignancy was 0.03% (10 cases) of all 29858 transplants of the time interval. Notably, cases of transmission were not from donors of this pool, but from donors that, according to our protocols, had no elements of suspect at time of donation. As recipient safety is always the priority and as guidelines have set exclusion criteria for donors with some specific types of malignancy, these results show that use of this type of donors is safe and improve organ pool. Furthermore represent basis for improvement and standardization of donor assessment protocols suggesting that efforts in data collection systems, to produce complete and homogeneous data, are mandatory. |
| Databáze: | OpenAIRE |
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