VERRUCOUS HYPERPLASIA AND VERRUCOUS CARCINOMA OF THE RAT ORAL MUCOSA
| Autor: | H. P. Philipsen, A. V. Fisker |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Male
Pathology medicine.medical_specialty 4-Nitroquinoline 1-oxide medicine.disease_cause Neoplasms Multiple Primary chemistry.chemical_compound Immunology and Microbiology (miscellaneous) medicine Carcinoma Animals Oral mucosa Carcinogen Gingival Neoplasms Hyperplasia Palatal Neoplasms General Immunology and Microbiology Verrucous carcinoma business.industry Mouth Mucosa Nitroquinolines Verrucous Lesion Rats Inbred Strains General Medicine medicine.disease 4-Nitroquinoline-1-oxide Carcinoma Papillary Rats Tongue Neoplasms medicine.anatomical_structure chemistry Carcinoma Squamous Cell Female Mouth Neoplasms Carcinogenesis business |
| Zdroj: | Acta Pathologica Microbiologica Scandinavica Series A :Pathology. :437-445 |
| ISSN: | 0108-0164 |
| Popis: | Verrucous hyperplasia and carcinoma are recognized entities in the human pathology, but not documented experimentally. During application of the carcinogen 4-nitroquinoline 1-oxide to the oral cavity of rats three times a week for a maximum of 18 weeks an increasing frequency of verrucous hyperplasias and carcinomas were noted. The majority of the carcinomas were localized to the palate and 3/4 of these were verrucous carcinomas, with or without anaplastic transformation to infiltrating squamous cell carcinomas. The oral verrucous lesions have all the histological characteristics of their human counterparts. The present experimental study supports the idea that tobacco consumption may represent an important etiological factor in the development of human, oral verrucous carcinomas. |
| Databáze: | OpenAIRE |
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