In Vitro Iontophoretic Transport of Ketorolac: Synthetic Membrane as a Barrier
| Autor: | Sandip B. Tiwari, Nayanabhirama Udupa |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Osmosis
Diffusion Synthetic membrane Pharmaceutical Science Electro-osmosis Models Biological Permeability Electricity medicine Cellulose Chromatography Iontophoresis Viscosity Chemistry Anti-Inflammatory Agents Non-Steroidal Membranes Artificial General Medicine Hydrogen-Ion Concentration Permeation In vitro Ketorolac Glucose Membrane medicine.drug |
| Zdroj: | Drug Delivery. 10:161-168 |
| ISSN: | 1521-0464 1071-7544 |
| DOI: | 10.1080/713840394 |
| Popis: | The effect of different factors on the iontophoretic transport of ketorolac was analyzed. In vitro experiments were performed in a diffusion cell with a cellulose membrane as a barrier. The results indicated that an increase in current density or drug concentration enhanced the transmembrane permeation of the drug. The presence of extraneous ions (such as NaCl) or an increase in viscosity of the donor medium slowed down the iontophoretic transport of the drug. The pH does not seem to be an important factor determining iontophoretic transport of ketorolac as statistically insignificant difference was observed in flux at pH 5.6, 7.2, and 8. Also, the relative importance of the transport contributions involved in iontophoresis, namely diffusive iontophoretic and electro-osmotic fluxes, was investigated using glucose as a nonionizable drug. The results indicated that the total flux of ketorolac is a result of two contributions: passive diffusion and iontophoretic flux. The contribution of electro-osmosis appears to be negligible. |
| Databáze: | OpenAIRE |
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