Immune response against SARS-CoV-2 variants: the role of neutralization assays
| Autor: | Anna Czarnota, Alicja M Chmielewska, Katarzyna Grzyb, Krystyna Bieńkowska-Szewczyk |
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| Rok vydání: | 2021 |
| Předmět: |
Pharmacology
biology viruses Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Immunology Neoplasms. Tumors. Oncology. Including cancer and carcinogens Review Article Disease RC581-607 medicine.disease_cause Vaccine efficacy Virology Neutralization Infectious Diseases Immune system Viral infection Pandemic medicine biology.protein Pharmacology (medical) Immunologic diseases. Allergy Neutralizing antibody RC254-282 Coronavirus |
| Zdroj: | NPJ Vaccines npj Vaccines, Vol 6, Iss 1, Pp 1-8 (2021) |
| ISSN: | 2059-0105 |
| Popis: | Since the emergence of the novel coronavirus SARS-CoV-2 in late 2019, the COVID-19 pandemic has hindered social life and global economic activity. As of July 2021, SARS-CoV-2 has caused over four million deaths. The rapid spread and high mortality of the disease demanded the international scientific community to develop effective vaccines in a matter of months. However, unease about vaccine efficacy has arisen with the spread of the SARS-CoV-2 variants of concern (VOCs). Time- and cost-efficient in vitro neutralization assays are widely used to measure neutralizing antibody responses against VOCs. However, the extent to which in vitro neutralization reflects protection from infection remains unclear. Here, we describe common neutralization assays based on infectious and pseudotyped viruses and evaluate their role in testing neutralizing responses against new SARS-CoV-2 variants. Additionally, we briefly review the recent findings on the immune response elicited by available vaccines against major SARS-CoV-2 variants, including Alpha, Beta, Gamma, and Delta. |
| Databáze: | OpenAIRE |
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