Consolidation and reconsolidation share behavioural and neurochemical mechanisms
Autor: | Sebastian M. Frank, Kazuhisa Shibata, Edward G. Walsh, Yuka Sasaki, Takeo Watanabe, Mark W. Greenlee, Ji Won Bang |
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Rok vydání: | 2018 |
Předmět: |
0301 basic medicine
Social Psychology Consolidation (soil) Consolidation process Glutamate receptor Experimental and Cognitive Psychology Similar time Inhibitory neurotransmitter Article Excitatory neurotransmitter 03 medical and health sciences Behavioral Neuroscience magnetic resonance spectroscopy (MRS) 030104 developmental biology 0302 clinical medicine Neurochemical reconsolidation excitatory and inhibitory balance Memory consolidation Psychology Neuroscience 030217 neurology & neurosurgery |
Zdroj: | Nature human behaviour |
ISSN: | 2397-3374 |
Popis: | After encoding, memory traces are fragile and easily disrupted by new learning until they are stabilized through a process termed consolidation1,2. However, several studies have suggested that consolidation does not make memory traces permanently stable. The results of these studies support the theory that the retrieval of previously consolidated memory, termed reactivation, renders the memory traces labile again and subject to disruption by new learning unless they go through a further consolidation process, termed reconsolidation3–8. However, it remains controversial whether reactivation and reconsolidation occur at a human behavioural level9–11 and whether consolidation and reconsolidation have common mechanisms12,13. Here, we found that reconsolidation does occur after reactivation in visual perceptual learning14–25, a type of skill learning, in humans. Moreover, changes in behavioural performance, as well as in concentrations in the excitatory neurotransmitter glutamate and in the inhibitory neurotransmitter GABA (γ-aminobutyric acid), as measured by magnetic resonance spectroscopy, in early visual areas exhibit similar time courses during consolidation and reconsolidation. These results indicate that reconsolidation after reactivation and consolidation in humans share common behavioural and neurochemical mechanisms. Shortly after retrieval, memory undergoes a labile period during which it can be modified. This study shows that this reconsolidation phase shows the same behavioural and neural characteristics as the initial learning phase. |
Databáze: | OpenAIRE |
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