Cerebral Blood Flow, Blood Volume, and Oxygen Metabolism Dynamics in Human Visual and Motor Cortex as Measured by Whole-Brain Multi-Modal Magnetic Resonance Imaging
| Autor: | Jakob Udby Blicher, David A. Feinberg, Bradley J. MacIntosh, Karla L. Miller, Matthias Günther, Manus J. Donahue, Peter Jezzard, Leif Østergaard |
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| Přispěvatelé: | Publica |
| Rok vydání: | 2009 |
| Předmět: |
Adult
genetic structures Contrast Media Blood volume Oxygen Consumption Nuclear magnetic resonance Neuroimaging medicine Humans Visual Cortex Blood Volume Blood Volume Determination medicine.diagnostic_test business.industry Motor Cortex Brain Magnetic resonance imaging Blood flow Magnetic Resonance Imaging Oxygen Kinetics Visual cortex medicine.anatomical_structure Neurology Cerebral blood flow Cerebrovascular Circulation Spin Labels Neurology (clinical) Cardiology and Cardiovascular Medicine Functional magnetic resonance imaging business Neuroscience circulatory and respiratory physiology Motor cortex |
| Zdroj: | Donahue, M, Blicher, J, Østergaard, L, Feinberg, D, MacIntosh, B, Miller, K, Gunther, M & Jezzard, P 2009, ' Cerebral blood flow, blood volume and oxygen metabolism dynamics in human visual and motor cortex as measured by whole-brain multi-modal magnetic resonance imaging ', Journal of Cerebral Blood Flow and Metabolism, vol. 29, no. 11, pp. 1856-1866 . https://doi.org/10.1038/jcbfm.2009.107 |
| ISSN: | 1559-7016 0271-678X |
| Popis: | The development of neuroimaging methods to characterize flow-metabolism coupling is crucial for understanding mechanisms that subserve oxygen delivery. Functional magnetic resonance imaging (fMRI) using blood-oxygenation-level-dependent (BOLD) contrast reflects composite changes in cerebral blood volume (CBV), cerebral blood flow (CBF), and the cerebral metabolic rate of oxygen consumption (CMRO2). However, it is difficult to separate these parameters from the composite BOLD signal, thereby hampering MR-based flow-metabolism coupling studies. Here, a novel, noninvasive CBV-weighted MRI approach (VASO-FLAIR with 3D GRASE (GRadient-And-Spin-Echo)) is used in conjunction with CBF-weighted and BOLD fMRI in healthy volunteers ( n=7) performing simultaneous visual (8 Hz flashing-checkerboard) and motor (1 Hz unilateral joystick) tasks. This approach allows for CBV, CBF, and CMRO2 to be estimated, yielding (mean±s.d.): ΔCBF=63%±12%, ΔCBV=17%±7%, and ΔCMRO2=13%±11% in the visual cortex, and ΔCBF=46%±11%, ΔCBV=8%±3%, and ΔCMRO2=12%±13% in the motor cortex. Following the visual and motor tasks, the BOLD signal became more negative ( P=0.003) and persisted longer ( P=0.006) in the visual cortex compared with the motor cortex, whereas CBV and CBF returned to baseline earlier and equivalently. The proposed whole-brain technique should be useful for assessing regional discrepancies in hemodynamic reactivity without the use of intravascular contrast agents. |
| Databáze: | OpenAIRE |
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