In silico, in vitro antimicrobial and antimycobacterial evaluation of newly synthesized 2r, 6c-diaryl-3t-methylpiperidin-4-one arylsulphonylhydrazones

Autor:	Malathi Balasubramaniyan, null Vimalraj Vinayagam, Moni Philip Jacob Kizhakedathil, null Pandiarajan Karuppiah
Rok vydání:	2022
Předmět:	Structure-Activity Relationship Anti-Infective Agents Organic Chemistry Drug Discovery Antitubercular Agents Hydrazones Microbial Sensitivity Tests Mycobacterium tuberculosis Molecular Biology Biochemistry Anti-Bacterial Agents
Zdroj:	Bioorganic chemistry. 128
ISSN:	1090-2120
Popis:	Eight 2r,6c-diaryl-3t-methylpiperidin-4-one arylsulphonylhydrazones 4(a-d) and 5(a-d) was synthesized by the condensation of benzenesulphonylhydrazide (2) or p-toluenesulphonylhydrazide (3) with 2r,6c-diaryl-3t-methylpiperidin-4-ones 1(a-d). The structural and molecular confirmations of the synthesized hydrazones were interpreted using 1D, 2D NMR spectra and CHNS analysis. The in silico studies of synthesized compounds 4(a-d) and 5(a-d) against b-ketoacyl-ACP-synthase III (FabH) indicated excellent anti-tubercular efficacy. The hydrazones were evaluated for antimicrobial activity and it was found that they exhibited significant antimicrobial activities. The in vitro evaluation of the compounds against Mycobacterium tuberculosis H
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6710edf7b0195e17a7d90f555fca98a4 https://pubmed.ncbi.nlm.nih.gov/35926427 Zobrazit plný text záznamu Full Text from ScienceDirect