Synthesis of Chlorotoxin by Native Chemical Ligation
| Autor: | Ulvi Karaca, Seçkin Kesici, Salih Özçubukçu |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
chemistry.chemical_classification
Engineering Chemical Stereochemistry Chlorotoxin solid phase peptide synthesis native chemical ligation Sequence (biology) Peptide General Chemistry Native chemical ligation solid phase peptide synthesis Mühendislik Kimya Amino acid lcsh:Chemistry chlorotoxin chemistry.chemical_compound Chlorotoxin lcsh:QD1-999 chemistry Peptide synthesis Linker Peptide sequence |
| Zdroj: | Volume: 5, Issue: 2 719-726 Journal of the Turkish Chemical Society Section A: Chemistry Journal of the Turkish Chemical Society, Section A: Chemistry, Vol 5, Iss 2, Pp 719-726 (2018) |
| ISSN: | 2149-0120 |
| Popis: | Chlorotoxin (CLTX) is a neurotoxin found in the venom of the Israeli scorpion, Leirius quinquestriatus. It contains 36-amino acids with four disulfide bonds and inhibits low-conductance chloride channels. CLTX also binds to matrix metalloproteinase-2 (MMP-2) selectively. The synthesis of chlorotoxin using solid phase peptide synthesis (SPPS) is very difficult and has a very low yield ( |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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