Role of chromatin remodeling gene Cecr2 in neurulation and inner ear development
| Autor: | Christine E. Dawe, Heather E. McDermid, Megan K. Kooistra, Amanda C. Pisio, Nicholas A. Fairbridge |
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| Rok vydání: | 2011 |
| Předmět: |
Male
Organogenesis Mutant Neuroepithelial Cells Nerve Tissue Proteins Exencephaly Biology Chromatin remodeling Mesoderm Mice medicine Animals Humans Inner ear Neural Tube Defects Neurulation Genetics Mice Inbred BALB C Microarray analysis techniques Neurogenesis Cell Polarity Embryo Mammalian Microarray Analysis medicine.disease Chromatin Cell biology Mice Inbred C57BL Neuroepithelial cell medicine.anatomical_structure Ear Inner Mutation Intercellular Signaling Peptides and Proteins Female sense organs Transcription Factors Developmental Biology |
| Zdroj: | Developmental Dynamics. 240:372-383 |
| ISSN: | 1058-8388 |
| DOI: | 10.1002/dvdy.22547 |
| Popis: | The loss of Cecr2, which encodes a chromatin remodeling protein, has been associated with the neural tube defect (NTD) exencephaly and open eyelids in mice. Here, we show that two independent mutations of Cecr2 are also associated with specific inner ear defects. Homozygous mutant 18.5 days post coitus (dpc) fetuses exhibited smaller cochleae as well as rotational defects of sensory cells and extra cell rows in the inner ear reminiscent of planar cell polarity (PCP) mutants. Cecr2 was expressed in the neuroepithelium, head mesenchyme, and the cochlear floor. Although limited genetic interaction for NTDs was seen with Vangl2, a microarray analysis of PCP genes did not reveal a direct connection to this pathway. The mechanism of Cecr2 action in neurogenesis and inner ear development is likely complex. Developmental Dynamics 240:372–383, 2011. © 2011 Wiley-Liss, Inc. |
| Databáze: | OpenAIRE |
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