Cortisol resistance in the New World revisited
| Autor: | Fraser M. Rogerson, Brian J. Smith, Peter J. Fuller |
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| Rok vydání: | 2004 |
| Předmět: |
Models
Molecular medicine.medical_specialty Hydrocortisone Endocrinology Diabetes and Metabolism medicine.medical_treatment Guinea Pigs Biology Tacrolimus Binding Proteins Guinea pig Receptors Glucocorticoid Endocrinology Glucocorticoid receptor In vivo Internal medicine medicine Animals HSP90 Heat-Shock Proteins Receptor chemistry.chemical_classification Amino acid Steroid hormone chemistry Cebidae hormones hormone substitutes and hormone antagonists Glucocorticoid Molecular Chaperones medicine.drug |
| Zdroj: | Trends in Endocrinology & Metabolism. 15:296-299 |
| ISSN: | 1043-2760 |
| DOI: | 10.1016/j.tem.2004.07.001 |
| Popis: | Insights into the molecular basis of glucocorticoid action have been obtained from the analysis of cortisol resistance. The glucocorticoid receptor (GR) in both New World primates and guinea pigs has a decreased affinity, in vivo, for cortisol; this is achieved by two distinct mechanisms. In the New World primates recent studies have identified a key role for co-chaperones. The amino acids responsible for cortisol resistance in the guinea pig GR lie not in the ligand-binding pocket but on the surface of the receptor. We hypothesize that this region might be the site of interaction between the co-chaperones and the GR, and hence that the resistance occurs through the same mechanism, albeit from opposite sides. |
| Databáze: | OpenAIRE |
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