Moderating effect of ppar-γ on the association of c-reactive protein and ischemic stroke in patients younger than 60
| Autor: | I. Ćelić, K. Starčević, Dubravka Kalinić, Ivana Karmelić, Ana Merkler, M. Šimić, Zdravka Poljaković, Jadranka Sertić, A. Bazina Martinović |
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| Rok vydání: | 2021 |
| Předmět: |
Male
medicine.medical_specialty Genotype Peroxisome proliferator-activated receptor chemistry.chemical_compound Internal medicine Genetics medicine Humans In patient Ischemic Stroke chemistry.chemical_classification biology Cholesterol C-reactive protein Protein level ishemic stroke serum CRP level PPAG CC genotype General Medicine Middle Aged PPAR gamma Endocrinology C-Reactive Protein chemistry Case-Control Studies Ischemic stroke biology.protein lipids (amino acids peptides and proteins) Female Body mass index |
| Zdroj: | Gene. 809 |
| ISSN: | 1879-0038 |
| Popis: | Aim The aim of this study was to evaluate the moderating effect of peroxisome proliferator activated receptor-γ (PPAR-γ) gene variants on the association of serum C-reactive protein level (CRP) and ischemic stroke (IS). Material and methods A total of 114 patients with IS and 135 healthy controls were included. Results After adjustment for age, sex, total cholesterol, LDL and HDL cholesterol, triglycerides, hypertension, smoking, body mass index and previous therapy with antihypertensive and/or statins, PPAR-γ had statistically significant moderating effect on association of serum CRP level and IS in patients younger than 60. In participants with PPAR CG or GG genotype level of CRP and IS were not statistically significantly associated (OR = 1.00; 95% CI 0.90–1.10; p = 0.933), but in participants with PPAR CC genotype, the association of serum CRP level and IS was significant (OR = 1.67; 95% CI 1.21–2.31; p = 0.002). Conclusion In patients with PPAR CC genotype the association of serum CRP level and IS was significant. |
| Databáze: | OpenAIRE |
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