Dietary interventions as regulators of stem cell behavior in homeostasis and disease
| Autor: | Sanjeethan C. Baksh, Elaine Fuchs, Jesse S S Novak |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_treatment
Niche Review Disease Biology Cell fate determination Diet High-Fat 03 medical and health sciences 0302 clinical medicine Stress Physiological Genetics medicine Animals Humans Organism 030304 developmental biology 0303 health sciences Stem Cells Fasting Lipid Metabolism Phenotype Diet Glucose 030220 oncology & carcinogenesis Stem cell Neuroscience Homeostasis Developmental Biology Ketogenic diet |
| Zdroj: | Genes Dev |
| ISSN: | 1549-5477 0890-9369 |
| Popis: | Stem cells maintain tissues by balancing self-renewal with differentiation. A stem cell's local microenvironment, or niche, informs stem cell behavior and receives inputs at multiple levels. Increasingly, it is becoming clear that the overall metabolic status of an organism or metabolites themselves can function as integral members of the niche to alter stem cell fate. Macroscopic dietary interventions such as caloric restriction, the ketogenic diet, and a high-fat diet systemically alter an organism's metabolic state in different ways. Intriguingly, however, they all converge on a propensity to enhance self-renewal. Here, we highlight our current knowledge on how dietary changes feed into stem cell behavior across a wide variety of tissues and illuminate possible explanations for why diverse interventions can result in similar stem cell phenotypes. In so doing, we hope to inspire new avenues of inquiry into the importance of metabolism in stem cell homeostasis and disease. |
| Databáze: | OpenAIRE |
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