Effect of Diallyl Trisulfide on the Pharmacokinetics of Nifedipine in Rats
| Autor: | Hong Zhou, Mei-Juan Zou, Yue Wang, Jungang Ren, Nan Zhao, Gang Cheng |
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| Rok vydání: | 2011 |
| Předmět: |
Male
Time Factors Nifedipine Metabolic Clearance Rate Vasodilator Agents Allyl compound Biological Availability Sulfides Pharmacology Plant Roots Rats Sprague-Dawley Food-Drug Interactions Random Allocation chemistry.chemical_compound Pharmacokinetics parasitic diseases mental disorders medicine Animals Garlic Plant Extracts Chemistry Reproducibility of Results food and beverages Half-life Calcium Channel Blockers Rats Allyl Compounds Diallyl trisulfide nervous system Concomitant Dietary Supplements Toxicity Platelet aggregation inhibitor Platelet Aggregation Inhibitors Half-Life Food Science medicine.drug |
| Zdroj: | Journal of Food Science. 76:T30-T34 |
| ISSN: | 0022-1147 |
| Popis: | This study aimed to evaluate the effect of diallyl trisulfide (DATS), a major component derived from garlic, on the pharmacokinetics of nifedipine. Pharmacokinetic parameters of nifedipine were determined in rats following an oral gavage (3 mg/kg) or intravenous administration (0.75 mg/kg) of nifedipine with co-administration of DATS (20 mg/kg) and long-term pretreatment of DATS (20 mg/kg/d for 15 consecutive days). Compared to the control groups, higher C(max) and AUC(0-24 h) were observed for oral gavage of nifedipine after short-term and long-term pretreatment of DATS, whereas those for intravenous nifedipine were little changed. The oral bioavailabilities of nifedipine were remarkably enhanced via the concomitant use of DATS. In conclusion, DATS increased the oral exposure of nifedipine in rats likely by the modification of intestinal metabolism of nifedipine, indicating that combined use of DATS or DATS-containing supplement with nifedipine may require caution because high plasma concentrations may lead to an undesired toxicity of this agent. Practical Application: Patients suffering from cardiovascular disease should take caution in combined use of DATS or DATS-rich garlic supplement with nifedipine because long-term treatment of DATS could lead high plasma concentrations of nifedipine. |
| Databáze: | OpenAIRE |
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