The ras oncoprotein and M-phase activity
| Autor: | A R Nebreda, Eugenio Santos, N Yew, I Daar, Michael Wigler, Richard S. Paules, Philip M. Sass, G F Vande Woude |
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| Rok vydání: | 1991 |
| Předmět: |
animal structures
Maturation-Promoting Factor Retroviridae Proteins Oncogenic Maturation promoting factor Xenopus Oncogene Proteins v-mos In Vitro Techniques Oncogene Protein p21(ras) Xenopus laevis Oogenesis medicine Animals Mitosis Metaphase reproductive and urinary physiology Cells Cultured Progesterone Multidisciplinary Embryonic cleavage biology Oncogene urogenital system Cell cycle Oocyte biology.organism_classification Molecular biology Meiosis medicine.anatomical_structure embryonic structures biology.protein |
| Zdroj: | Science (New York, N.Y.). 253(5015) |
| ISSN: | 0036-8075 |
| Popis: | The endogenous mos proto-oncogene product (Mos) is required for meiotic maturation. In Xenopus oocytes, the ras oncogene product (Ras) can induce meiotic maturation and high levels of M-phase--promoting factor (MPF) independent of endogenous Mos, indicating that a parallel pathway to metaphase exists. In addition, Ras, like Mos and cytostatic factor, can arrest Xenopus embryonic cell cleavage in mitosis and maintain high levels of MPF. Thus, in the Xenopus oocyte and embryo systems Ras functions in the M phase of the cell cycle. The embryonic cleavage arrest assay is a rapid and sensitive test for Ras function. |
| Databáze: | OpenAIRE |
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