Expression of membrane complement regulators, CD46, CD55 and CD59, in mesothelial cells of patients on peritoneal dialysis therapy
| Autor: | Claire L. Harris, Masashi Mizuno, Michitaka Fujiwara, Yasuhiro Kodera, Yumi Sei, Daiki Iguchi, Seiichi Matsuo, Yasuhiro Suzuki, Fumiko Sakata, Shoichi Maruyama, Yasuhiko Ito, Masaki Imai, Keiko Higashide |
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| Rok vydání: | 2015 |
| Předmět: |
Male
medicine.medical_treatment Immunology Renal function CD59 Antigens CD59 Epithelium Icodextrin Peritoneal dialysis Membrane Cofactor Protein Andrology chemistry.chemical_compound Peritoneum medicine Humans Complement Activation Molecular Biology Creatinine Interleukin-6 CD46 Membrane Proteins Epithelial Cells Complement System Proteins CD56 Antigen body regions medicine.anatomical_structure Gene Expression Regulation chemistry CA-125 Antigen Female Peritoneal Dialysis Mesothelial Cell |
| Zdroj: | Molecular Immunology. 65:302-309 |
| ISSN: | 0161-5890 |
| Popis: | We investigated the expression of membrane complement regulators (CRegs), CD46, CD55 and CD59 in human mesothelial cells, and correlated with clinical background and level of complement (C) activation products in peritoneal dialysis (PD) fluids (PDF) to clarify influence of the C activation system in PD patients. Expression of CRegs was assessed on primary cultures of mesothelial cells (HPMC) harvested from PD fluid of 31 PD patients. Because expression of CD55 but not CD46 and CD59 in mesothelial cells was significantly correlated to value of dialysate-to-plasma creatinine concentration ratio (D/P Cre) (p |
| Databáze: | OpenAIRE |
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