The prognostic value of ADRA1 subfamily genes in gastric carcinoma
| Autor: | Tingan Wang, Yuzhou Qin, Zhao Li, Jiansi Chen, Mingwei Huang, Yang Yang, Hao Lai, Wei-yuan Wei |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Oncology Cancer Research medicine.medical_specialty Subfamily Alpha-1B adrenergic receptor 03 medical and health sciences 0302 clinical medicine Internal medicine adrenergic receptor α1 subfamily medicine gastric carcinoma Alpha-1D adrenergic receptor Oncogene Proportional hazards model business.industry Hazard ratio mRNA expression Articles Hyperplasia medicine.disease Molecular medicine 030104 developmental biology 030220 oncology & carcinogenesis prognosis business |
| Zdroj: | Oncology Letters |
| ISSN: | 1792-1074 |
| Popis: | Adrenergic receptor α1 (ADRA1) subfamily members, including ADRA1A, ADRA1B and ADRA1D, are understood to participate in cardiac disease and benign prostatic hyperplasia. In addition, adrenergic signals in cell pathways can promote the development of cancer. However, little is understood regarding the associations between ADRA1 subfamily members and gastric carcinoma (GC). The present study investigated the prognostic value of the ADRA1 subfamily genes in GC. Data from a total of 379 patients with GC were obtained from The Cancer Genome Atlas and Gene Expression Omnibus databases. Kaplan-Meier analysis and Cox regression analysis were used to determine associations with overall survival (OS) and to evaluate the median survival time using hazard ratios (HRs) and 95% confidence intervals (CIs). Multivariate survival analysis revealed that low expression levels of ADRA1A (HR, 0.595; 95% CI, 0.426-0.831; adjusted P=0.002) ADRA1B (HR, 0.576; 95% CI, 0.412-0.805; adjusted P=0.001) and ADRA1D (HR, 0.559; 95% CI, 0.398-0.787; adjusted P=0.001) were associated with a favourable OS. Joint-effects analysis demonstrated that combinations of low expression levels of ARDA1A, ARDA1B and ARDA1D were significantly associated with a favourable OS. Overall, the current results suggested that the mRNA expression levels of ARDA1 subfamily members may serve as potential prognostic markers for GC. |
| Databáze: | OpenAIRE |
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