Polymorphism of the E-cadherin geneCDH1is associated with susceptibility to vitiligo
| Autor: | Roberto Gomes Tarlé, Caio Cesar Silva de Castro, Liliane Machado do Nascimento, Marcelo Távora Mira |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Male
Melanocyte adhesion Interleukin-1beta Population Vitiligo Comorbidity Dermatology Biology Polymorphism Single Nucleotide Biochemistry Autoimmune Diseases CDH1 Nephroblastoma Overexpressed Protein Discoidin Domain Receptor 1 Antigens CD Cell Adhesion medicine Humans Genetic Predisposition to Disease Allele skin and connective tissue diseases Cell adhesion education Molecular Biology Gene Genetic Association Studies education.field_of_study integumentary system Cadherin Receptor Protein-Tyrosine Kinases Cadherins medicine.disease Cancer research biology.protein Melanocytes Female |
| Zdroj: | Experimental Dermatology. 24:300-302 |
| ISSN: | 0906-6705 |
| DOI: | 10.1111/exd.12641 |
| Popis: | Vitiligo is a depigmenting disorder characterized by loss of functional melanocytes from the epidermis. Experimental data suggest that defective melanocyte adhesion may underlie the pathogenesis of the disease. In particular, association between vitiligo and genetic variants of the DDR1 gene involved in melanocyte adhesion has been recently published. A subsequent, independent study revealed lower expression of DDR1 in vitiligo lesions. Here, we expand this investigation by testing for association between vitiligo and polymorphisms of CDH1, IL1B and NOV (formerly CCN3), genes belonging to the DDR1 adhesion pathway, in two population samples of distinct design. Our results reveal that alleles of marker rs10431924 of the CDH1 gene are associated with vitiligo, especially in the presence of autoimmune comorbidities. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|