Extracorporeal Photopheresis: An Efficacious and Well-Tolerated Treatment for Cutaneous and Oral Mucosal Chronic Graft-versus-Host Disease
| Autor: | Marie Claude Marguery, Cristina Bulai Livideanu, Benoit Lepage, Chloé Dimeglio, Cécile Borel, Serge Boulinguez, Camille Richet, Carle Paul, Anne Huynh |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Adult
Male medicine.medical_specialty Lichenoid Eruptions medicine.medical_treatment Graft vs Host Disease Dermatology Single Center Gastroenterology Tacrolimus Mycophenolic acid 03 medical and health sciences 0302 clinical medicine Photopheresis Prednisone Internal medicine Extracorporeal Photopheresis medicine Humans Adverse effect Skin Sclerosis business.industry Hematopoietic Stem Cell Transplantation Mouth Mucosa Middle Aged Mycophenolic Acid medicine.disease Tolerability 030220 oncology & carcinogenesis Lichenoid eruption Chronic Disease Cyclosporine Female Mouth Diseases business Immunosuppressive Agents 030215 immunology medicine.drug |
| Zdroj: | Dermatology. 234:23-30 |
| ISSN: | 1421-9832 1018-8665 |
| DOI: | 10.1159/000488238 |
| Popis: | Background: Extracorporeal photopheresis (ECP) is a second-line therapy for steroid-refractory chronic graft-versus-host disease (cGVHD). Objective: We describe the long-term efficacy and tolerability of ECP according to the cutaneous phenotype of cGVHD and report on the reduced need for immunosuppressant drugs in this setting. Patients and Methods: Fourteen patients (8 females) with cutaneous and/or mucosal cGVHD, treated with ECP between October 2010 and May 2016 within a single center, were included. Final analyses included patients who had received ECP for at least 12 months. We prospectively evaluated the efficacy of ECP using lesion-specific clinical scores and by recording changed doses of systemic immunosuppressants. Results: Of the 14 patients, sclerotic skin lesions were present in 10 (71%). The mRODNAN score decreased in all patients from month 9 onwards, with 40 and 77% reductions at 12 and 36 months, respectively. Six patients (43%) presented with cutaneous lichenoid lesions: this score was reduced in all patients by month 3, reaching a 93% reduction by month 12. Five patients (36%) experienced oral mucosal lichenoid lesions: these scores were decreased by 55% at month 12 and by 100% by month 33. The use of systemic immunosuppressants was reduced in all patients; 4 patients could stop all immunosuppressant drugs after 2 years. ECP was stopped in 3 patients after a complete response. No major ECP-associated adverse effects were observed. Discussion and Conclusion: ECP was an effective long-term therapy for oral and cutaneous cGVHD: consequently, dose levels of therapeutic immunosuppression could be reduced. |
| Databáze: | OpenAIRE |
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