Antimicrobial activity of a novel aminoglycoside, ACHN-490, against Acinetobacter baumannii and Pseudomonas aeruginosa from New York City
| Autor: | Neha Shah, David Landman, John Quale, Elizabeth Babu, Paul Kelly, Simona Bratu, Martin Bäcker |
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| Rok vydání: | 2010 |
| Předmět: |
Acinetobacter baumannii
Microbiology (medical) medicine.drug_class Polymyxin Microbial Sensitivity Tests Drug resistance Biology Plazomicin medicine.disease_cause Microbiology chemistry.chemical_compound Drug Resistance Multiple Bacterial medicine Humans Pharmacology (medical) Pharmacology Pseudomonas aeruginosa Aminoglycoside biochemical phenomena metabolism and nutrition bacterial infections and mycoses Antimicrobial biology.organism_classification Anti-Bacterial Agents Aminoglycosides Infectious Diseases chemistry Amikacin Sisomicin New York City medicine.drug |
| Zdroj: | Journal of Antimicrobial Chemotherapy. 66:332-334 |
| ISSN: | 1460-2091 0305-7453 |
| DOI: | 10.1093/jac/dkq459 |
| Popis: | Multidrug-resistant Acinetobacter baumannii and Pseudomonas aeruginosa have become a global problem, often leaving the polymyxins as therapeutic agents of last resort. ACHN-490, a next-generation aminoglycoside with activity against a broad range of Gram-positive and Gram-negative pathogens, was examined against clinical isolates of A. baumannii and P. aeruginosa.The activity of aminoglycosides and ACHN-490 was determined against a contemporary collection of A. baumannii and P. aeruginosa. Selected aminoglycoside-resistant isolates were screened for the presence of genes encoding common aminoglycoside-modifying enzymes and methylases.Resistance to the traditional aminoglycosides was common in the collection of A. baumannii. ACHN-490 possessed superior activity against these isolates, with an MIC(50) value of 8 mg/L. In P. aeruginosa, the activity of ACHN-490 was similar to that of amikacin (MIC(50) value of 8 mg/L for both agents). For both A. baumannii and P. aeruginosa, the MICs of ACHN-490 did not correlate with the presence of commonly encountered aminoglycoside-modifying enzymes.For A. baumannii, the MICs of ACHN-490 were lower than those of traditional aminoglycosides. For P. aeruginosa, the activity of ACHN-490 was similar to that of amikacin. |
| Databáze: | OpenAIRE |
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