A modular approach to easily processable supramolecular bilayered scaffolds with tailorable properties
| Autor: | Marta Comellas-Aragonès, A. J. H. Spiering, Björne B. Mollet, Patricia Y. W. Dankers, E. W. Meijer, Serge H. M. Söntjens |
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| Přispěvatelé: | Macromolecular and Organic Chemistry |
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
chemistry.chemical_classification
Scaffold Materials science Biomedical Engineering Supramolecular chemistry Biomaterial Nanotechnology General Chemistry General Medicine Polymer Electrospinning 3. Good health chemistry.chemical_compound chemistry Tissue engineering Polycaprolactone General Materials Science Adhesive Composite material |
| Zdroj: | Journal of Materials Chemistry B, 2(17), 2483-2493. Royal Society of Chemistry |
| ISSN: | 2050-7518 2050-750X |
| DOI: | 10.1039/C3TB21516D |
| Popis: | Engineering of anisotropic tissues demands extracellular matrix (ECM) mimicking scaffolds with an asymmetric distribution of functionalities. We here describe a convenient, modular approach based on supramolecular building blocks to form electrospun bilayered scaffolds with tailorable properties. Polymers and peptides functionalized with hydrogen-bonding ureido-pyrimidinone (UPy) moieties can easily be mixed-and-matched to explore new material combinations with optimal properties. These combinatorial supramolecular biomaterials, processed by electrospinning, enable the formation of modular fibrous scaffolds. We demonstrate how UPy-functionalized polymers based on polycaprolactone and poly(ethylene glycol) enable us to unite both cell-adhesive and non-cell adhesive characters into a single electrospun bilayered scaffold. We furthermore show that the non-cell adhesive layer can be bioactivated and made adhesive for kidney epithelial cells by the incorporation of 4 mol% of UPy-modified Arg-Gly-Asp (RGD) peptide in the electrospinning solution. These findings show that the UPy-based supramolecular biomaterial system offers a versatile toolbox to form modular multilayered scaffolds for tissue engineering and regenerative medicine applications such as the formation of membranes for a living bioartificial kidney. |
| Databáze: | OpenAIRE |
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