Alterations in erythrocyte membrane lipids in abetalipoproteinemia: Phospholipid and fatty acyl composition
| Autor: | Takashi Sekiya, Masaka Kawade, Satoshi Maeda, Masahiko Kawamura, Hisaya Iida, Yoshiki Takashima, Yoshinori Nozawa, Yukio Okano |
|---|---|
| Rok vydání: | 1984 |
| Předmět: |
Male
food.ingredient Lipoproteins Linoleic acid Phospholipid Lignoceric acid Acanthocytes Biology Biochemistry Lecithin Palmitic acid Membrane Lipids chemistry.chemical_compound food Humans Phospholipids Erythrocyte Membrane Fatty Acids Infant Abetalipoproteinemia Sphingomyelins Cholesterol chemistry Docosahexaenoic acid Microscopy Electron Scanning Phosphatidylcholines Female lipids (amino acids peptides and proteins) Arachidonic acid Sphingomyelin |
| Zdroj: | Biochemical Medicine. 32:79-87 |
| ISSN: | 0006-2944 |
| DOI: | 10.1016/0006-2944(84)90010-3 |
| Popis: | Scanning electron microscopic observation revealed that there were wide variations including typical acanthocytes in morphology of erythrocytes from a patient with abetalipoproteinemia. The erythrocyte membrane phospholipids and cholesterol contents from a patient was higher by 25% compared to an age-matched control subject. Analysis of phospholipid composition of red blood cells showed an increase of sphingomyelin (25.1 → 30.1%) with a concomitant decrease of lecithin (27.5 → 21.0%). Thus, the sphingomyelin/lecithin ratio was increased dramatically (0.91 → 1.43). As for fatty acyl chain composition of main phospholipids, an increased percentage of palmitic acid and docosahexaenoic acid and a decreased proportion of arachidonic acid and lignoceric acid were observed for sphingomyelin. There was an increment of palmitic acid which was accompanied with a decrease of linoleic acid in lecithin. On the other hand, no significant difference was shown in the fatty acid composition of phosphatidylethanolamine and phosphatidylserine plus phosphatidylinositol between a patient and control. |
| Databáze: | OpenAIRE |
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