The impact of CCR5-Δ32 deletion on C-reactive protein levels and cardiovascular disease:Results from the Danish Blood Donor Study
| Autor: | Margit Hørup Larsen, Bjarne Kuno Møller, Henrik Hjalgrim, Erik Sørensen, Mikkel Steen Petersen, Khoa Manh Dinh, Kathrine Agergård Kaspersen, Cecilie J. Sørensen, Ole Birger Pedersen, Christian Erikstrup, Henrik Ullum |
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| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Adult
Genetic Markers Male medicine.medical_specialty Heterozygote Receptors CCR5 Chemokine receptor CCR5 Denmark Inflammation Disease Risk Assessment Danish Risk Factors Internal medicine Epidemiology medicine Humans Genetic Predisposition to Disease Genotyping biology business.industry C-reactive protein Homozygote Middle Aged language.human_language Hospitalization C-Reactive Protein Phenotype Cardiovascular Diseases Cohort Immunology language biology.protein Female medicine.symptom Cardiology and Cardiovascular Medicine business Biomarkers Gene Deletion |
| Zdroj: | Dinh, K M, Pedersen, O B, Petersen, M S, Sørensen, E, Sørensen, C J, Kaspersen, K A, Larsen, M H, Møller, B, Hjalgrim, H, Ullum, H & Erikstrup, C 2015, ' The impact of CCR5-Δ32 deletion on C-reactive protein levels and cardiovascular disease : Results from the Danish Blood Donor Study ', Atherosclerosis, vol. 242, no. 1, pp. 222-5 . https://doi.org/10.1016/j.atherosclerosis.2015.07.031 |
| DOI: | 10.1016/j.atherosclerosis.2015.07.031 |
| Popis: | BACKGROUND AND PURPOSE: The C-C chemokine receptor 5-Δ32 deletion (CCR5-Δ32) has been associated with lower levels of C-reactive protein (CRP), but the effect on cardiovascular diseases is uncertain. This study addresses the impact of CCR5-Δ32 on the risk of low-grade inflammation and hospitalization with cardiovascular diseases in a large cohort of blood donors.METHODS: Genotyping of 15,206 healthy participants from The Danish Blood Donor Study for CCR5-Δ32 was performed and combined with CRP measurements and questionnaire data. Cardiovascular disease diagnoses were identified by ICD-10 codes in the Danish National Patient Registry.RESULTS: CCR5-Δ32-carriers had a higher risk of hospitalization for cardiovascular diseases when compared with wild-type homozygotes (hazard ratio = 1.35, 95%-confidence interval: 1.00-1.87). CRP levels were unaffected by the CCR5-Δ32 deletion.CONCLUSION: In this cohort, carriers of the CCR5-Δ32 deletion had normal CRP levels but a borderline significant increased risk of cardiovascular diseases. |
| Databáze: | OpenAIRE |
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