Helicobacter pylori eradication can induce platelet recovery in chronic idiopathic thrombocytopenic purpura

Autor:	Nada Suvajdžić, Vera Artiko, Tanja Cvejić, Milica Colovic, Henry Dushan E. Atkinson, Vladislava Bulat, Milena Bakrac, Boris Stanković, Vladimir Obradović
Rok vydání:	2006
Předmět:	Adult Blood Platelets Male medicine.medical_specialty Population Spleen Gastroenterology Helicobacter Infections Internal medicine medicine Humans Platelet Prospective Studies education Aged Breath test Purpura Thrombocytopenic Idiopathic education.field_of_study Helicobacter pylori biology medicine.diagnostic_test business.industry Platelet recovery Remission Induction Chronic idiopathic thrombocytopenic purpura Recovery of Function Hematology General Medicine Middle Aged biology.organism_classification Anti-Bacterial Agents medicine.anatomical_structure Breath Tests Chronic Disease Cohort Immunology Drug Therapy Combination Female business
Zdroj:	Platelets. 17:227-230
ISSN:	1369-1635 0953-7104
DOI:	10.1080/09537100500462487
Popis:	We prospectively investigated the prevalence of Helicobacter pylori (H. pylori) infection in a cohort of 54 adult Serbian patients with chronic idiopathic thrombocytopenic purpura (ITP), and examined the effects of its eradication on their platelet counts. H. pylori infection was diagnosed in 39/54 (72.2%) patients, using the 14C-urea breath test; and was significantly higher than in the healthy Serbian population (55% P0.05). H. pylori-positive patients were significantly older than H. pylori-negative patients (P = 0.006), though there were no significant differences regarding gender, disease duration, mean platelet counts, previous therapies and spleen status between H. pylori-positive and H. pylori-negative patients. Successful eradication was confirmed in 23/30 (77%) treated patients. Stable platelet recovery was registered in 6/23 eradicated patients (26.1%) and maintained for 18 months. Complete and partial remissions were achieved in two and four patients, respectively, including one highly refractory patient. A significant mean platelet recovery was seen 6 months after successful H. pylori eradication in the group of 23 patients (P0.05). No platelet recovery was registered in either H. pylori-negative (n = 15), untreated H. pylori-positive patients (n = 9) or H. pylori-positive non-eradicated patients (n = 7). Even though the pathogenetic mechanisms of H. pylori-induced thrombocytopenia remain obscure, the results of this small prospective study support the use of H. pylori eradication as an effective non-immunosuppressive treatment for chronic ITP.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66f896f45d452d4bfa677ef06ef6ce22 https://doi.org/10.1080/09537100500462487 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
Nepřihlášeným uživatelům se plný text nezobrazuje	K zobrazení výsledku je třeba se přihlásit.