Controlled ovarian stimulation with exclusive FSH followed by stimulation with hCG alone, FSH alone or hMG
| Autor: | Marcos Dias de Moura, Rosana Maria dos Reis, Mariana Kefalás Oliveira Gomes, Carolina Sales Vieira, Luiz Alberto Manetta, Rui Alberto Ferriani, Stael Porto Leite |
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| Rok vydání: | 2005 |
| Předmět: |
Adult
endocrine system medicine.medical_specialty Menotropins Pregnancy Rate medicine.medical_treatment media_common.quotation_subject Chorionic Gonadotropin Human chorionic gonadotropin Follicle-stimulating hormone Ovulation Induction Pregnancy Internal medicine Follicular phase medicine Humans Prospective Studies Ovarian follicle Ovulation Progesterone media_common business.industry Obstetrics and Gynecology Fertility Agents Female medicine.disease Recombinant Proteins Menopause medicine.anatomical_structure Endocrinology Reproductive Medicine Follicular Phase Ovulation induction Female Follicle Stimulating Hormone Luteinizing hormone business hormones hormone substitutes and hormone antagonists |
| Zdroj: | European journal of obstetrics, gynecology, and reproductive biology. 130(1) |
| ISSN: | 0301-2115 |
| Popis: | Objective To assess if low-dose hCG is similar to hMG and to rFSH in the late follicular phase. Study design In a prospective randomized controlled trial, 51 patients undergoing controlled ovarian stimulation received ovarian priming with rFSH and then received hCG (200 IU/day) (hCG group, n = 17), hMG (225 IU/day) (hMG group, n = 17) or rFSH (200 IU/day) (FSH group, n = 17) in the late stage of follicular development. Parameters of follicular response and serum estradiol, progesterone and testosterone levels were assessed. Results Pre-ovulatory ovarian follicle occurrence and length of treatment were similar among the three treatment groups. Serum progesterone level on the day of pre-ovulatory hCG was significantly higher in the hCG group than in the hMG or rFSH group. Clinical pregnancy rates were similar for all groups. The total cost of treatment was significantly lower for the hCG group than for the groups supplemented with hMG or rFSH. Conclusions LH in the form of low-dose hCG during the late follicular phase induced the same follicular pattern as hMG and rFSH after ovulation induction. The procedure using hCG produced pregnancy rates similar to those obtained using hMG and rFSH, even though the patients showed higher serum progesterone levels on the hCG day. |
| Databáze: | OpenAIRE |
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