Malignant syndromes: current advances
| Autor: | Xuefeng Wang, Minghua Tao, Xin Tian, Jiyuan Li |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
medicine.medical_treatment Disease 030204 cardiovascular system & hematology Antiparkinson Agents 03 medical and health sciences 0302 clinical medicine Altered Mental Status medicine Humans Neuroleptic Malignant Syndrome Pharmacology (medical) Antipsychotic Anesthetics biology business.industry Incidence Incidence (epidemiology) Parkinson Disease General Medicine Prognosis Dermatology Malignant syndrome Pathophysiology Muscular Rigidity 030220 oncology & carcinogenesis biology.protein Creatine kinase Malignant Hyperthermia business Antipsychotic Agents |
| Zdroj: | Expert Opinion on Drug Safety. 20:1075-1085 |
| ISSN: | 1744-764X 1474-0338 |
| DOI: | 10.1080/14740338.2021.1919622 |
| Popis: | Introduction: Many drugs are known to induce malignant syndromes. The most common malignant syndromes are induced by the use of antipsychotics and anesthetics and the withdrawal of anti-Parkinson drugs. As the clinical manifestations of antipsychotic malignant syndrome, Parkinson's disease hyperpyrexia syndrome and anesthetic-induced malignant syndrome are very similar, they are easily confused in the clinic.Areas covered: We reviewed articles published between 1960 and April 2021 describing malignant syndromes. This paper provides a detailed literature review of malignant syndromes and important guidance for the diagnosis and treatment of malignant syndromes to clinicians.Expert opinion: Although malignant syndromes are rare conditions with a low incidence, these conditions usually progress rapidly and can endanger patients' lives, meriting attention from clinicians. The typical clinical manifestations of malignant syndromes are hyperpyrexia, muscular rigidity, an altered mental status and increased levels of creatine kinase; however, the pathophysiology, treatment and prognosis of different malignant syndromes are quite different. Prompt diagnosis and treatment may significantly improve the prognosis of patients with malignant syndromes. |
| Databáze: | OpenAIRE |
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