Amyloid-beta accumulation, neurogenesis, behavior, and the age of rats
| Autor: | Gerald D. Silverberg, Miles C. Miller, Conrad E. Johanson, Doreen P. Osgood, David Freestone, Russell M. Church, Arthur Messier, Jason T. Machan, Catharine Chiu |
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| Rok vydání: | 2014 |
| Předmět: |
Male
Aging medicine.medical_specialty Amyloid beta Neurogenesis Motor Activity Rage (emotion) Behavioral Neuroscience Discrimination Psychological Internal medicine medicine Animals skin and connective tissue diseases Temporal discrimination Amyloid beta-Peptides Age differences biology business.industry Age Factors Brain Membrane Transport Proteins Transporter Peptide Fragments Rats Inbred F344 Rats Endocrinology biology.protein Conditioning Operant sense organs Stem cell business |
| Zdroj: | Behavioral Neuroscience. 128:523-536 |
| ISSN: | 1939-0084 0735-7044 |
| DOI: | 10.1037/a0036433 |
| Popis: | The goals of this research were to describe age-related changes in brain biochemistry and behavior, and the relationships between them. The chronological ages of greatest change are particularly important for targeting interventions. In this experiment, 36 Fischer 344/Brown-Norway rats (3, 12, 20, and 30 months old) were trained in lever boxes on temporal discrimination tasks. The greatest response rate decrease and response pattern change occurred between 12 and 20 months. The biochemical results showed that amyloid-beta peptides (Aβ40 and Aβ42) increased with age. The endothelial expression of the Aβ influx transporter (RAGE) also increased, and the expression of Aβ efflux transporter (LPR-1) decreased, with age. The greatest change in the biochemical measures also were between 12 and 20 months. Twenty additional rats were analyzed for stem cell proliferation, and neurogenesis decreased with age, particularly between about 12 and 20 months. These early changes in brain, biochemistry, and behavior provide opportunity for new therapies or prophylaxis. |
| Databáze: | OpenAIRE |
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