Vaccination of mice against Schistosoma bovis with a recombinant fatty acid binding protein from Fasciola hepatica
| Autor: | George V. Hillyer, P. Casanueva, J.López Abáné, J.L. Pérez Arellano, Ana Oleaga, Antonio Muro, V. Ramajo |
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| Rok vydání: | 2000 |
| Předmět: |
animal structures
Antibodies Helminth Heterologous Nerve Tissue Proteins Cross immunity Fatty Acid-Binding Proteins Myelin P2 Protein law.invention Microbiology Mice Immune system law Hepatica parasitic diseases Animals Schistosomiasis Fasciola hepatica General Veterinary biology Vaccination Helminth Proteins General Medicine biology.organism_classification Virology Isotype Recombinant Proteins Neoplasm Proteins Mice Inbred C57BL Liver biology.protein Recombinant DNA Schistosoma Parasitology Rabbits Antibody Carrier Proteins Fatty Acid-Binding Protein 7 |
| Zdroj: | Veterinary Parasitology. 91:33-42 |
| ISSN: | 0304-4017 |
| DOI: | 10.1016/s0304-4017(00)00263-6 |
| Popis: | Two strains of mice (NMRI and C57/BL) were each immunized with a 15 kDa recombinant Fasciola hepatica fatty acid binding protein (FABP) (Fh15) and challenged percutaneously with Schistosoma bovis cercariae. C57/BL mice immunized with Fh15 had significant reductions in S. bovis worm burden recoveries (72% reductions over controls). When using NMRI mice, Fh15 in Freund’s adjuvant failed to induce significant protection against S. bovis . In C57/BL mice, only antibodies to the IgG2a isotype increased after the second immunization and remained high through 8 weeks of S. bovis infection. This is the first time that a heterologous recombinant molecule from F. hepatica has been used in vaccination against S. bovis , obtaining a significant reduction in the number of worms in C57/BL mice. |
| Databáze: | OpenAIRE |
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