Prenatal exposure to perfluoroalkyl and polyfluoroalkyl substances and childhood atopic dermatitis: a prospective birth cohort study

Autor: Yi-Feng Guo, Li Hua, Rong Huang, Yanjun Zhao, Xia Wang, Qian Chen, Lisu Huang, Jun Zhang
Rok vydání: 2017
Předmět:
0301 basic medicine
Male
Health
Toxicology and Mutagenesis
010501 environmental sciences
01 natural sciences
Umbilical cord
Perfluorononanoic acid
chemistry.chemical_compound
Pregnancy
Prospective Studies
Perfluoroalkyl and polyfluoroalkyl substances
Fluorocarbons
Obstetrics
lcsh:Public aspects of medicine
Cord blood
Atopic dermatitis
Fetal Blood
medicine.anatomical_structure
Quartile
Alkanesulfonic Acids
Maternal Exposure
Prenatal Exposure Delayed Effects
lcsh:Industrial medicine. Industrial hygiene
Environmental Pollutants
Female
Adult
medicine.medical_specialty
China
Offspring
Dermatitis
Atopic
Exposure
03 medical and health sciences
lcsh:RC963-969
Young Adult
Statistical significance
medicine
Humans
Cities
0105 earth and related environmental sciences
business.industry
Research
Public Health
Environmental and Occupational Health
Infant
Newborn
Infant
lcsh:RA1-1270
Odds ratio
medicine.disease
Childhood
Confidence interval
030104 developmental biology
chemistry
business
Zdroj: Environmental Health
Environmental Health, Vol 17, Iss 1, Pp 1-12 (2018)
ISSN: 1476-069X
Popis: Background Perfluoroalkyl and polyfluoroalkyl substances (PFASs) have been reported to suppress immune function. However, previous studies on prenatal exposure to PFASs and allergic disorders in offspring provided inconsistent results. We aimed to examine the association between prenatal exposure to PFASs and childhood atopic dermatitis (AD) in offspring up to 24 months of age. Methods A prospective birth cohort study involving 1056 pregnant women was conducted in two hospitals in Shanghai from 2012 to 2015. Prenatal information was collected by an interview with the women and from medical records. Fetal umbilical cord blood was collected at birth. Cord blood plasma PFASs were measured. Children were followed at 6, 12 and 24 months and information on the development of AD was recorded. AD was diagnosed by 2 dermatologists independently based on the questionnaires. Multiple logistic regression was used to compute odds ratio (OR) and corresponding 95% confidence interval (CI) for the association between AD and each PFASs, adjusting for potential confounders. Results A total of 687 children completed a 2-year follow-up visit and had PFASs measurement. AD was diagnosed in 173 (25.2%) children during the first 24 months. In female children, a log-unit increase in perfluorooctanoic acid (PFOA) was associated with a 2.1-fold increase in AD risk (AOR 2.07, 95% CI 1.13–3.80) after adjusting for potential confounders. The corresponding risk was 2.22 (1.07–4.58) for perfluorononanoic acid (PFNA). The highest PFOA quartile was significantly associated with AD (2.52, 1.12–5.68) compared with the lowest quartile. The highest quartile of PFNA, perfluorodecanoic acid (PFDA) and perfluorohexane sulfonic acid (PFHxS) were associated with AD with AOR (95% CI) being 2.14 (0.97–4.74), 2.14 (1.00–4.57), and 2.30 (1.03–5.15), respectively. Additionally, the second quartile of perfluorododecanoic acid (PFDoA) was associated with a 3.2-fold increase in AD risk (3.24, 1.44–7.27). However, no significant associations were found in male children. Conclusions Prenatal exposure to PFOA, PFDA, PFDoA and PFHxS significantly increased the risk of childhood AD in female children during the first 24 months of life. In addition, the associations between AD with prenatal exposure to PFNA were close to statistical significance. Electronic supplementary material The online version of this article (10.1186/s12940-018-0352-7) contains supplementary material, which is available to authorized users.
Databáze: OpenAIRE
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