Release of corticotropin after administration of corticotropin-releasing hormone in depressed patients in relation to the dexamethasone suppression test
| Autor: | Bengt Kjellman, B. Kågedal, Gunnar Akner, Björn Wahlund, Lennart Wetterberg, J.-G. Ljunggren, B. E. Thalén |
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| Rok vydání: | 1993 |
| Předmět: |
Adult
Male endocrine system medicine.medical_specialty Hydrocortisone Corticotropin-Releasing Hormone Stimulation Dexamethasone Corticotropin-releasing hormone Adrenocorticotropic Hormone Internal medicine medicine Humans Major depressive episode Aged Depressive Disorder Area under the curve Middle Aged Pathophysiology Psychiatry and Mental health Endocrinology Dexamethasone suppression test Female medicine.symptom Psychology hormones hormone substitutes and hormone antagonists medicine.drug Hormone |
| Zdroj: | Acta psychiatrica Scandinavica. 87(2) |
| ISSN: | 0001-690X |
| Popis: | The possible hypersecretion involvement of corticotropin-releasing hormone (CRH) in the pathophysiology of hypothalamic-pituitary-adrenocortical axis disturbances in patients with major depressive episode and with an abnormal dexamethasone suppression test (DST) was investigated. The corticotropin (ACTH) and cortisol response to the injection of 45 micrograms of synthetic human CRH at 1630 were analyzed in 24 inpatients with normal (suppressors) or abnormal (nonsuppressors) DST. The outcome of the DST was analyzed using 3 cut-off points for the cortisol levels. The clinical assessments included two rating scales. The results showed that nonsuppressors had a significantly lower ACTH response to CRH stimulation than suppressors at all cut-off points (calculated as net area under the curve and as the difference between the peak and the baseline level) despite no significant differences in the severity of depression. |
| Databáze: | OpenAIRE |
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