Synthesis and anticoccidial activity of 4-(2-methoxyphenyl) -2-oxo-butyl-quinazolinone derivatives

Autor: Xihao Mo, Junhui You, Yabiao Weng, Changwen Ye, Yuliang Wang
Rok vydání: 2008
Předmět:
Zdroj: ARKIVOC, Vol 2008, Iss 17, Pp 1-11 (2008)
ISSN: 1551-7012
DOI: 10.3998/ark.5550190.0009.h01
Popis: A series of 4-(2-methoxyphenyl)-2-oxo-butyl-quinazolinones were designed and synthesized based on the structure of febrifugine. The structures of the new compounds were confirmed by H NMR, C NMR, IR spectra and HRMS. The biological activity test results indicated that they exhibited anticoccidial activities against Eimeria tenella in the chicken diet with a dose of 9 mg/kg. Compared with halofuginone, these compounds have the advantages of shorter synthetic routes and lower cost.
Databáze: OpenAIRE