Cortical OFF-potentials from the S-cone pathway reveal neural damage in early glaucoma
| Autor: | Yousef H. Aldebasi, James Edwards Morgan, Neville Drasdo, Rachel Valerie North |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
medicine.medical_specialty
Open angle glaucoma genetic structures Eye disease Glaucoma Visual evoked potentials Visual system Sensitivity and Specificity Optics Cone pathway Ophthalmology medicine Humans Visual Pathways Aged Visual Cortex business.industry S-cones Early glaucoma Middle Aged medicine.disease eye diseases Sensory Systems Visual cortex medicine.anatomical_structure Case-Control Studies Retinal Cone Photoreceptor Cells Evoked Potentials Visual sense organs business Glaucoma Open-Angle |
| Zdroj: | Vision Research. 43(2):221-226 |
| ISSN: | 0042-6989 |
| DOI: | 10.1016/s0042-6989(02)00435-2 |
| Popis: | We used background adaptation and silent substitution techniques to record full-field ON and OFF-visually evoked cortical potentials (VECPs) selectively from the S-cone and L- and M-cone pathways in 15 patients with primary open angle glaucoma (POAG), and 15 normal controls. The most statistically significant (P=0.01) VECP test for POAG was a voltage change in the S-cone pathway cortical OFF-response. A sensitivity of 93% was achieved, with 60% specificity at minimum error rate. This is presumed to reflect reduced activity in the S-cone and magnocellular visual pathways, and may provide an effective method for research and monitoring change in early glaucoma. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect