Effects of two fentanyl constant rate infusions on thermal thresholds and plasma fentanyl concentrations in awake cats
| Autor: | Jane Alcorn, Barbara Ambros, Maria Valentina Carrozzo |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
040301 veterinary sciences
Sedation Loading dose Body Temperature Fentanyl 0403 veterinary science 03 medical and health sciences 0302 clinical medicine Pharmacokinetics 030202 anesthesiology Post-hoc analysis medicine Animals Single-Blind Method Infusions Intravenous Cross-Over Studies CATS Dose-Response Relationship Drug General Veterinary business.industry 04 agricultural and veterinary sciences Crossover study Analgesics Opioid Anesthesia Cats Female Analysis of variance medicine.symptom business medicine.drug |
| Zdroj: | Veterinary Anaesthesia and Analgesia. 45:831-838 |
| ISSN: | 1467-2987 |
| DOI: | 10.1016/j.vaa.2018.06.006 |
| Popis: | Objective To determine the pharmacokinetics and effects on thermal thresholds (TT) of two fentanyl constant rate infusions in awake cats. Study design A blinded, randomized crossover study. Animals A group of six healthy female cats, aged 3 ± 1 years, weighing 4.1 ± 0.7 kg. Methods Skin temperature (TSKIN) and TT were evaluated using a wireless TT device. TSKIN, TT, sedation score (SS) and blood samples were collected before an intravenous loading dose (LD; over 5 seconds) and at specific time points during (360 minutes) and after infusion. Each cat was administered two treatments: fentanyl (LD 3 μg kg−1, infusion 3 μg kg−1 hour−1; treatment F3) or fentanyl (LD 5 μg kg−1, infusion 5 μg kg−1 hour−1; treatment F5). SS between treatments was analyzed using a Kruskal–Wallis test. Statistical analysis of TT and TSKIN was performed using analysis of variance with appropriate post hoc test (p Results TSKIN did not vary over time for each treatment. SS did not differ between treatments. TTs were significantly higher than baseline at 15 minutes after LD for F3 and F5. TT was significantly increased at 30, 90, 120, 180 and 300 minutes in treatment F5 but not in F3. Plasma fentanyl concentrations decreased rapidly in both treatments over the first 30 minutes after infusion. The terminal half-life was 3.31 (2.93–4.41) hours for F3 and 3.67 (3.39–4.32) hours for F5 (median, range). Systemic clearance for treatments F3 and F5 was 1.95 (1.46–2.44) and 2.25 (1.98–2.47) L hour−1 kg−1 (median, range), respectively. Plasma concentrations Conclusions and clinical relevance A fentanyl infusion rate of 5 μg kg−1 hour−1 increased TT during the infusion period. Effects on TT were lost rapidly with cessation of the infusion. |
| Databáze: | OpenAIRE |
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