CD6 expression has no effect on atherosclerosis in apolipoprotein E-deficient mice

Autor:	Gospel Enyindah-Asonye, Jonathan D. Smith, Feng Lin, Juying Han
Jazyk:	angličtina
Rok vydání:	2018
Předmět:	Antigens Differentiation T-Lymphocyte Male 0301 basic medicine Apolipoprotein E medicine.medical_specialty Cell lcsh:Medicine Biology General Biochemistry Genetics and Molecular Biology Lesion Mice 03 medical and health sciences chemistry.chemical_compound Apolipoproteins E High-density lipoprotein Antigens CD Internal medicine medicine Deficient mouse Animals lcsh:Science (General) lcsh:QH301-705.5 Aorta Mice Knockout B-Lymphocytes Cholesterol lcsh:R CD6 General Medicine Atherosclerosis Research Note Disease Models Animal B1a cells 030104 developmental biology medicine.anatomical_structure Endocrinology chemistry lcsh:Biology (General) Mice Inbred DBA Diet Atherogenic Female medicine.symptom Surface protein Natural IgM Natural antibody lcsh:Q1-390
Zdroj:	BMC Research Notes, Vol 11, Iss 1, Pp 1-5 (2018) BMC Research Notes
ISSN:	1756-0500
DOI:	10.1186/s13104-018-3327-4
Popis:	Objective To determine if deficiency of CD6, a cell surface protein on lymphocytes that alters natural antibody production, increases atherosclerosis in ApoE-deficient mice fed a chow or a western-type diet. Results We compared cholesterol levels, IgM, B1a cells, and aortic root lesion areas in ApoE-deficient vs. CD6/ApoE double deficient mice. Feeding the high-fat western type diet increased all parameters, except for B1a cell numbers decreased. Sex also had an effect on many parameters with males having increased body weights, higher high density lipoprotein cholesterol, higher B1a cells, but smaller atherosclerotic lesions if chow fed mice; however, this sex effect on atherosclerosis was absent in mice fed the western-type diet. CD6 deficiency had no effect on atherosclerosis in both male and female mice on either diet. Thus, loss of CD6 on lymphocytes did not lead to expected reductions in B1a cells and protective IgM levels, and in turn did not alter atherosclerosis in mice.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66eaaa356091985600be817aa4e3134d http://link.springer.com/article/10.1186/s13104-018-3327-4 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
Nepřihlášeným uživatelům se plný text nezobrazuje	K zobrazení výsledku je třeba se přihlásit.