No genetic overlap between circulating Iron Levels and Alzheimer's disease
| Autor: | Lupton, MK, Benyamin, B, Proitsi, P, Nyholt, DR, Ferreira, MA, Montgomery, GW, Heath, AC, Madden, PA, Medland, SE, Gordon, SD, Consortium, GERAD1, Initiative, Alzheimer’s Disease Neuroimaging, Lovestone, S, Tsolaki, M, Kloszewska, I, Soininen, H, Mecocci, P, Vellas, B, Powell, JF, Bush, AI, Wright, MJ, Martin, NG, Whitfield, JB |
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| Přispěvatelé: | Lupton, Michelle K, Benyamin, Beben, Proitsi, Petroula, Nyholt, Dale R, Whitfield, John B, GERAD1 Consortium, Faculty of Health Sciences, shared activities |
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Male Genome-wide association study Disease Bioinformatics genetic profile scores Cohort Studies 0302 clinical medicine iron chemistry.chemical_classification Aged 80 and over medicine.diagnostic_test General Neuroscience General Medicine Middle Aged Alzheimer's disease apolipoproteins E dementia ferritin genome-wide association study population genetics transferrin Clinical Psychology Geriatrics and Gerontology Psychiatry and Mental Health Serum iron Female Alzheimer’s disease Alzheimer's Disease Neuroimaging Initiative Biology Polymorphism Single Nucleotide Community Health Planning 03 medical and health sciences Meta-Analysis as Topic Alzheimer Disease medicine Dementia Humans Genetic Association Studies Aged medicine.disease Ferritin 030104 developmental biology chemistry Transferrin Immunology Ferritins biology.protein 030217 neurology & neurosurgery |
| Zdroj: | Lupton, M K, Benyamin, B, Proitsi, P, Nyholt, D R, Ferreira, M A, Montgomery, G W, Heath, A C, Madden, P A, Medland, S E, Gordon, S D, Lovestone, S, Tsolaki, M, Kloszewska, I, Soininen, H, Mecocci, P, Vellas, B, Powell, J F, Bush, A I, Wright, M J, Martin, N G & Whitfield, J B 2017, ' No Genetic Overlap between Circulating Iron Levels and Alzheimer's Disease ', JOURNAL OF ALZHEIMERS DISEASE, vol. 59, no. 1, pp. 85-99 . https://doi.org/10.3233/JAD-170027 |
| DOI: | 10.3233/JAD-170027 |
| Popis: | Article Iron deposition in the brain is a prominent feature of Alzheimer’s disease (AD). Recently, peripheral iron measures have also been shown to be associated with AD status. However, it is not known whether these associations are causal: do elevated or depleted iron levels throughout life have an effect on AD risk? We evaluate the effects of peripheral iron on AD risk using a genetic profile score approach by testing whether variants affecting iron, transferrin, or ferritin levels selected from GWAS meta-analysis of approximately 24,000 individuals are also associated with AD risk in an independent case-control cohort (n∼10,000). Conversely, we test whether AD risk variants from a GWAS meta-analysis of approximately 54,000 account for any variance in iron measures (n∼9,000). We do not identify a genetic relationship, suggesting that peripheral iron is not causal in the initiation of AD pathology. final draft http://purl.org/eprint/status/PeerReviewed |
| Databáze: | OpenAIRE |
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