Periostin Expression and Its Prognostic Value for Colorectal Cancer
Autor: | Sanhui Yang, Zhaogang Dong, Chuanxin Wang, Yongmei Yang, Zewu Li, Lili Wang, Lutao Du, Xin Zhang |
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Rok vydání: | 2015 |
Předmět: |
Male
Oncology medicine.medical_specialty Colorectal cancer colorectal cancer Periostin Biology Article Catalysis survival analysis Metastasis lcsh:Chemistry Inorganic Chemistry Extracellular matrix Focal adhesion Internal medicine Biomarkers Tumor medicine Humans Neoplasm Invasiveness Neoplasm Metastasis Physical and Theoretical Chemistry lcsh:QH301-705.5 Molecular Biology Spectroscopy Survival analysis Cell adhesion molecule Organic Chemistry General Medicine Middle Aged Prognosis medicine.disease Up-Regulation Computer Science Applications lcsh:Biology (General) lcsh:QD1-999 immunohistochemistry Immunohistochemistry Female Colorectal Neoplasms Cell Adhesion Molecules POSTN |
Zdroj: | International Journal of Molecular Sciences Volume 16 Issue 6 Pages 12108-12118 International Journal of Molecular Sciences, Vol 16, Iss 6, Pp 12108-12118 (2015) |
ISSN: | 1422-0067 |
Popis: | Integrin is important for cell growth, invasion and metastasis, which are frequently observed in malignant tumors. The periostin (POSTN) gene encodes the ligand for integrin, one of the key focal adhesion proteins contributing to the formation of a structural link between the extracellular matrix and integrins. High expression levels of the POSTN gene are correlated with numerous human malignancies. We examined POSTN protein in colorectal cancer specimens from 115 patients by strictly following up using immunohistochemistry. Cytoplasm immunohistochemical staining showed POSTN protein expression in colorectal cancers. The positive expression rate of POSTN protein (59.13%, 68/115) in colorectal cancers was significantly higher than that in adjacent normal colon mucosa (0.47%, 11/109). POSTN over-expression in colorectal cancers was positively correlated with tumor size, differentiation, lymph node metastasis, serosal invasion, clinical stage and five-year survival rates. Further analysis showed that patients with advanced stage colorectal cancer and high POSTN expression levels had lower survival rates than those with early stage colorectal cancer and low POSTN expression levels. Overall, our results showed that POSTN played an important role in the progression of colorectal cancers. |
Databáze: | OpenAIRE |
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