Prolonged Penile Erections Induced by Hydroxyzine: Possible Mechanism of Action

Autor:	J. X. Thavundayil, B. Krishnan, Samarthji Lal, N.M.K. Ng Ying Kin, R. Hambalek
Rok vydání:	1994
Předmět:	Adult Male Models Molecular Penile erections Norchlorcyclizine Metabolite Molecular Conformation Poison control Piperazines Structure-Activity Relationship chemistry.chemical_compound M-chlorophenylpiperazine medicine Humans Priapism Biological Psychiatry Hydroxyzine business.industry musculoskeletal neural and ocular physiology Insect Bites and Stings Trazodone Serotonin Receptor Agonists Psychiatry and Mental health Neuropsychology and Physiological Psychology Mechanism of action chemistry Anesthesia medicine.symptom business circulatory and respiratory physiology medicine.drug
Zdroj:	Neuropsychobiology. 30:4-6
ISSN:	1423-0224 0302-282X
DOI:	10.1159/000119126
Popis:	We describe a subject who developed prolonged penile erections on hydroxyzine. Molecular modelling showed that the hydroxyzine metabolite, norchlorcyclizine, has structural and conformational similarities to the trazodone metabolite, m-chlorophenylpiperazine. This suggests that a common pharmacological mechanism may underlie the ability of trazodone and hydroxyzine to induce erections.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66e5d4927e34d65366cb4247884ee467 https://doi.org/10.1159/000119126 Zobrazit plný text záznamu