Relationship between periodontal outcomes and serum biomarkers changes after non-surgical periodontal therapy
| Autor: | José Eduardo Batista, Rosana Costa Casanovas de Carvalho, Vandilson Pinheiro Rodrigues, Isaac Suzart Gomes-Filho, Antônio Luiz Pereira, Walder Jansen Mello de Lobão, Sandra Augusta de Moura Leite |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Adult
Male 0301 basic medicine medicine.medical_specialty Periodontal treatment Cell Count Gastroenterology C-reactive protein 03 medical and health sciences 0302 clinical medicine Serum biomarkers Albumins Internal medicine Inflammatory marker medicine Leukocytes Humans lcsh:Science Aged Multidisciplinary business.industry Interleukin-6 Case-control study Albumin Inflammation mediators 030206 dentistry Middle Aged medicine.disease Chronic periodontitis Clinical trial Treatment Outcome 030104 developmental biology Case-Control Studies Correlation analysis Female lcsh:Q business Biomarkers |
| Zdroj: | Anais da Academia Brasileira de Ciências, Vol 91, Iss 2 (2019) Anais da Academia Brasileira de Ciências v.91 n.2 2019 Anais da Academia Brasileira de Ciências Academia Brasileira de Ciências (ABC) instacron:ABC Anais da Academia Brasileira de Ciências, Volume: 91, Issue: 2, Article number: e20170652, Published: 23 MAY 2019 |
| ISSN: | 1678-2690 |
| Popis: | The systemic effect of chronic periodontitis (CP) has been suggested by several studies as an etiologic factor and modulator of diseases based on the changes in the inflammatory marker levels. This study aimed to investigate the relationship between the changes in clinical periodontal outcomes and serum biomarkers (CRP, IL-6, albumin and percentage of leukocytes) after non-surgical periodontal therapy in systemically healthy adults. An interventional study was conducted with a sample of 29 individuals without CP (control group) and 33 with CP (CP group). Periodontal clinical variables were recorded, and the serum levels of inflammatory markers were measured. Statistical analysis included the chi-square and Student’s t-tests and Pearson’s correlation analysis. After 90 days of non-surgical periodontal treatment, a reduction of periodontal parameters and IL-6 in both groups could be observed (P < 0.001). The correlation analysis revealed a directly proportional correlation between changes in the probing depth (r = 0.349, P = 0.049) and clinical attachment level (r = 0.374, P = 0.034) with CRP in the CP group. The findings suggest a reduction of IL-6 serum concentration and periodontal clinical measures 90 days after periodontal therapy in both groups. |
| Databáze: | OpenAIRE |
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