Safety and Effectiveness of the Prolonged Treatment of Children with a Ketogenic Diet
| Autor: | Laura Andrea Puerta Macfarland, Beatriz García Alcolea, Elvira Cañedo Villarroya, Consuelo Pedrón Giner, Begoña Gómez Fernández, Juan José García Peñas, Jana Ruiz Herrero |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Male
Pediatrics medicine.medical_specialty Drug Resistant Epilepsy Time Factors medicine.medical_treatment growth Nutritional Status 030209 endocrinology & metabolism lcsh:TX341-641 Article 03 medical and health sciences Epilepsy 0302 clinical medicine Child Development drug-resistant epilepsy Risk Factors medicine Humans Hypercalciuria Prospective Studies Child Growth Disorders Retrospective Studies Nutrition and Dietetics business.industry Age Factors Infant Anthropometry medicine.disease Anticonvulsant Treatment Outcome glut-1 Epilepsy in children ketogenic diet Child Preschool Observational study Female business Child Nutritional Physiological Phenomena Diet Ketogenic Nutritive Value lcsh:Nutrition. Foods and food supply 030217 neurology & neurosurgery Food Science Ketogenic diet |
| Zdroj: | Nutrients, Vol 12, Iss 2, p 306 (2020) Nutrients Volume 12 Issue 2 |
| ISSN: | 2072-6643 |
| Popis: | Background: The ketogenic diet (KD) is an effective treatment against drug-resistant epilepsy in children. The KD is a diet rich in fats that produces anticonvulsant and neuroprotective effects that reduces seizures and improves the cognitive state. Nevertheless, it can produce side effects that sometimes can be serious. Further, the effect on growth is quite controversial when used for an extended period of time. The aim of this paper was to assess the effectiveness, side effects, and repercussions in the development of children who have been treated with a KD for more than 2 years. Methods: Observational descriptive study of 26 pediatric patients on a KD, with data collection at baseline, at 3, 6, and 12 months, and then once a year. Number of seizures, type of seizures, anti-seizure drugs, anthropometry, side effects, and alterations in laboratory assessment were monitored. Results: In every assessment, about 60%&ndash 75% of the patients experienced a reduction in number of seizures of over 90%, and at least 50% experienced side effects, of which digestive issues, alteration in the lipid metabolism, and hypercalciuria were the most common. The KD significantly affected height after 2 years of treatment. Conclusions: The KD is an effective treatment for drug-resistant epilepsy. Its side effects, although common, are very mild therefore, this constitutes a very safe treatment for children of all ages. More studies are needed to identify and prevent potential causes of growth retardation in children on the KD. |
| Databáze: | OpenAIRE |
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