A Review of Low-Intensity Pulsed Ultrasound for Therapeutic Applications
| Autor: | Yufeng Li, Oleksandra Savchenko, Xiaoxue Jiang, Jie Chen, Tianlin Yang, Wei Zhang, Shiang Qi |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Inflammation
Soft Tissue Injuries business.industry Ultrasonic Therapy 0206 medical engineering Pulsed Ultrasound Ultrasound Biomedical Engineering Tissue heating Acoustic energy Target tissue 02 engineering and technology Low-intensity pulsed ultrasound 020601 biomedical engineering Neuromodulation (medicine) 3. Good health Fractures Bone Ultrasonic Waves Transcutaneous Electric Nerve Stimulation Delayed union Animals Humans Medicine business Biomedical engineering |
| Zdroj: | IEEE Transactions on Biomedical Engineering. 66:2704-2718 |
| ISSN: | 1558-2531 0018-9294 |
| DOI: | 10.1109/tbme.2018.2889669 |
| Popis: | Ultrasound therapy has a long history of novel applications in medicine. Compared to high-intensity ultrasound used for tissue heating, low-intensity ultrasound has drawn increasing attention recently due to its ability to induce therapeutic changes without biologically significant temperature increase. Low-intensity pulsed ultrasound (LIPUS) is a specific type of ultrasound that delivers at a low intensity and outputs in the mode of pulsed waves. It has minimal thermal effects while maintaining the transmission of acoustic energy to the target tissue, which is able to provide noninvasive physical stimulation for therapeutic applications. LIPUS has been demonstrated to accelerate the healing of fresh fracture, nonunion and delayed union in both animal and clinical studies. The effectiveness of LIPUS for the applications of soft-tissue regeneration and inhibiting inflammatory responses has also been investigated experimentally. Additionally, research has shown that LIPUS is a promising modality for neuromodulation. The purpose of this review is to provide an overview of the recent developments of LIPUS for therapeutic applications, based on the papers that report positive effects, and to present the findings on the understanding of its mechanism. Current available LIPUS devices are also briefly described in this paper. |
| Databáze: | OpenAIRE |
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