Cypovirus capsid protein VP5 has nucleoside triphosphatase activity
| Autor: | Jie Yang, Qi Qian, Xueli Yang, Teng-Feng Li, Sok Jin Won, Xi Zhou |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Letter viruses 030106 microbiology Immunology Reoviridae 03 medical and health sciences Structure-Activity Relationship Virology Viral rna Nucleoside triphosphatase activity Nucleoside-triphosphatase Adenosine Triphosphatases biology Chemistry RNA biology.organism_classification Nucleoside-Triphosphatase Recombinant Proteins 030104 developmental biology Biochemistry Capsid Mutation Molecular Medicine Capsid Proteins Cypovirus Molecular Chaperones |
| Zdroj: | Virologica Sinica. 32(4) |
| ISSN: | 1995-820X |
| Popis: | As a major protein of cypovirus capsid shell,VP5 performs as the clamp protein to stabilize the capsid shell structure (Yu et al.,2008).And as a part of viral RNA (vRNA) replication machinery,VP5 has been found to possess an ATP-independent RNA chaperoning activity (Yang et al.,2014).Here,we report that VP5 also has the nucleoside triphosphatase (NTPase) activity,which can hydrolyze all kinds of NTPs and dNTPs.Thus,our finding reveals that VP5 is a multifunctional protein that may be involved in diverse processes during cypoviral life cycle. |
| Databáze: | OpenAIRE |
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