Histopathological features of epithelioid malignant pleural mesotheliomas in patients with extended survival
| Autor: | Jarmo A. Salo, Eeva Kettunen, Mikko I. Mäyränpää, Ilkka Ilonen, Jari Räsänen, Tapio Vehmas, Henrik Wolff, Hely Ollila, Eva Sutinen, Marjukka Myllärniemi, Juuso Paajanen, Sanna Laaksonen |
|---|---|
| Přispěvatelé: | HUS Heart and Lung Center, Keuhkosairauksien yksikkö, University of Helsinki, Helsinki University Hospital Area, INDIVIDRUG - Individualized Drug Therapy, Research Programs Unit, Faculty of Medicine, HUSLAB, Department of Pathology, III kirurgian klinikka, Clinicum, Department of Surgery, Department of Medicine, Medicum |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Male Mesothelioma medicine.medical_specialty Pathology Necrosis Lung Neoplasms Time Factors Survival Pleural Neoplasms Histopathology Autopsy Epithelioid mesothelioma medicine.disease_cause DIAGNOSIS Asbestos Pathology and Forensic Medicine 03 medical and health sciences 0302 clinical medicine Asbestos fibers medicine MANAGEMENT Humans In patient HYPERPLASIA grade business.industry Epithelioid Cells Mesothelioma Malignant Hyperplasia medicine.disease 3. Good health PREDICTS 030104 developmental biology Treatment Outcome 030220 oncology & carcinogenesis 3121 General medicine internal medicine and other clinical medicine GRADING SYSTEM Female 3111 Biomedicine medicine.symptom Neoplasm Grading Lung tissue business DIFFERENTIATED PAPILLARY MESOTHELIOMA |
| Zdroj: | Human pathology. 98 |
| ISSN: | 1532-8392 |
| Popis: | Diffuse malignant mesothelioma (DMM) of the pleura is a rare and aggressive disease, where the long-term survival (LTS) rate is low. The epithelioid subtype is the most prevalent form of DMM with the best prognosis. In order to study prognostic histopathologic factors associated with extended survival in epithelioid DMM, we examined 43 tumors from patients with survival over five years (long-term survivals [LTS]) and compared the findings with 84 tumors from a reference group with average survival (RG). We analyzed the tumors considering previously published histopathological prognostic features and attempted to identify additional morphological features predictive of extended survival. Most of the LTS tumors presented with nuclear grade I (n = 34,90%) and a tubulopapillary growth pattern (n = 30,70%). One LTS tumor had necrosis. In contrast, nuclear grade II (n = 49,61%) and solid growth pattern (n = 59,70%) were more frequent in RG, and necrosis was present in 16 (19%) tumors. We also evaluated the association of asbestos lung tissue fiber burden quantified from autopsy samples with histopathological features and found that elevated asbestos fiber was associated with higher nuclear grade (p |
| Databáze: | OpenAIRE |
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