Dose-rate effect on transgenerational mutation frequencies in spermatogonial stem cells of the Medaka Fish
| Autor: | Atsuko Shimada, Akihiro Shima, Shinji Yoshinaga, Hoshio Eguchi |
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| Jazyk: | angličtina |
| Rok vydání: | 2005 |
| Předmět: |
Male
DNA Mutational Analysis Oryzias Biophysics Biology Radiation Dosage Chromosomes Mice Gene Frequency Species Specificity Transgenerational epigenetics health services administration mental disorders Animals Spermatogonial stem cells Radiology Nuclear Medicine and imaging Mutation frequency Genetic risk Spermatogenesis Cells Cultured Chromosome Aberrations Genetics Radiation Stem Cells Dose-Response Relationship Radiation Molecular biology humanities Gamma Rays Total dose Mutation (genetic algorithm) Fish Dose rate |
| Zdroj: | Radiation Research. 163:112-114 |
| ISSN: | 0033-7587 |
| Popis: | Shimada, A., Eguchi, H., Yoshinaga, S. and Shima, A. Dose-Rate Effect on Transgenerational Mutation Frequencies in Spermatogonial Stem Cells of the Medaka Fish. Radiat. Res. 163, 112–114 (2005). The estimation of transgenerational genetic risk of radiation exposure to non-human species is crucial for the protection of ecosystems. Here we determined the frequency of specific-locus mutations at the five pigmentation loci in medaka spermatogonial stem cells after γ irradiation at 0.03 cGy/min and 95 cGy/min. At each total dose, the mutation frequency was significantly lower in the 0.03-cGy/min group than in the 95-cGy/min group, suggesting a dose-rate effect. The ratio of the induced mutation frequency at 0.03 cGy/min to that at 95 cGy/min was ∼0.42 from 0 to 1.9 Gy and ∼0.33 from 1.9 to 4.75 cGy. In the mouse, this ratio is estimated to be 0.33 (Russell and Kelly, Proc. Natl. Acad. Sci. USA 79, 542–544, 1982). It is thus possible that the magnitude of the dose-rate effect on transgenerational mutat... |
| Databáze: | OpenAIRE |
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