Minoxidil for Treatment of Resistant Hypertension in Chronic Kidney Disease--A Retrospective Cohort Analysis
| Autor: | Alexander Lammert, Bernhard K. Krämer, Heiko M. Mundt, Uwe Gottmann, Urs Benck, Rainer Birck, Matthias Matenaer |
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| Rok vydání: | 2016 |
| Předmět: |
Male
medicine.medical_specialty Endocrinology Diabetes and Metabolism Resistant hypertension Vasodilation 030204 cardiovascular system & hematology 03 medical and health sciences 0302 clinical medicine Pharmacotherapy Internal medicine Internal Medicine medicine Humans 030212 general & internal medicine Renal Insufficiency Chronic Adverse effect Antihypertensive Agents Aged Retrospective Studies Inpatients Treatment Resistant Hypertension business.industry Retrospective cohort study Middle Aged medicine.disease Treatment Outcome Blood pressure Endocrinology Minoxidil Hypertension Cardiology Drug Therapy Combination Female Cardiology and Cardiovascular Medicine business Kidney disease medicine.drug |
| Zdroj: | J Clin Hypertens (Greenwich) |
| ISSN: | 1524-6175 |
| DOI: | 10.1111/jch.12847 |
| Popis: | Resistant hypertension is still a challenge and reserve antihypertensive agents are often necessary to achieve blood pressure control. One reserve antihypertensive is minoxidil, a direct vasodilator that is known for its strong blood pressure–lowering effect, but contemporary studies are sparse. The authors retrospectively analyzed 54 inpatients with uncontrolled hypertension despite the combined use of current antihypertensive agents. To investigate the effect of minoxidil when added to other antihypertensive agents, blood pressure was evaluated at the time minoxidil treatment was initiated and at discharge. Minoxidil treatment was associated with a significant reduction in blood pressure from 162.4±15.1/83.2±12.7 mm Hg to 135.8±12.2/72.8±6.9 mm Hg (P |
| Databáze: | OpenAIRE |
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