Genome-wide association study identifies susceptibility loci for acute myeloid leukemia

Autor: Anne M. Dickinson, Gail Jones, David C. Linch, Clare Lendrem, David Grimwade, Richard A. Larson, Andrew D. Skol, Yaobo Xu, Adam Ivey, Wei-Yu Lin, Manja Meggendorfer, Rosemary E. Gale, Inés Gómez-Seguí, Giovani Marconi, Jean Norden, Jude Fitzgibbon, Mette K. Andersen, M Bornhäuser, Sarah E. Fordham, Amanda F. Gilkes, Heinz Sill, Eric A. Hungate, José Cervera, Friedrich Stölzel, Julia Gaal-Wesinger, Kim Piechocki, Wendy Stock, Theresa Hahn, Konstantin Strauch, David Allsup, Kenan Onel, Claire Elstob, Alyssa I. Clay-Gilmour, Nicola J. Sunter, Jelena D. Milosevic Feenstra, Meyling Cheok, Abrar Alharbi, Ann K. Daly, Sally Jeffries, Lisa Wagenführ, Olaf Heidenreich, Robert Kralovics, Alan K. Burnett, Giovanni Martinelli, Desiree Kunadt, Christian Gieger, Francesco Lo-Coco, Leo Ruhnke, Maria Teresa Voso, Junke Wang, Catherine Park, Nigel H. Russell, Chimène Moreilhon, Robert Kerrin Hills, Claude Preudhomme, Graham Jackson, Daniel Nowak, Maria Chiara Fontana, James M. Allan, Heidi Altmann, Richard S. Houlston, Anne S. Quante, Michelle M. Le Beau, Thahira Rahman, Christoph Röllig, Rebecca Darlay, Sophie Raynaud, Helen Marr, Csaba Bödör, Louise Palm, Thomas Cluzeau, Szilvia Krizsán, Heather J. Cordell, Mathew Collin, Torsten Haferlach, Lara E. Sucheston-Campbell, Wolf-Karsten Hofmann, Kimmo Porkka, Andras Masszi, Hervé Dombret, Miguel A. Sanz, Elisabeth Douglas, Tobias Menne
Přispěvatelé: HUS Comprehensive Cancer Center, University Management, Helsinki University Hospital Area, Department of Oncology, Hematologian yksikkö
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Oncology
General Physics and Astronomy
Genome-wide association study
Disease
0302 clinical medicine
AML
HLA Antigens
hemic and lymphatic diseases
Histone methylation
Cancer genomics
RISK
0303 health sciences
Multidisciplinary
Myeloid leukemia
Middle Aged
CLONAL EVOLUTION
CANCER
3. Good health
HLA
Leukemia
Myeloid
Acute
030220 oncology & carcinogenesis
GENE-MUTATIONS
medicine.medical_specialty
Genotype
Science
Locus (genetics)
HIF-1-ALPHA
Human leukocyte antigen
Polymorphism
Single Nucleotide
Article
Acute myeloid leukaemia
General Biochemistry
Genetics and Molecular Biology
03 medical and health sciences
Aldehyde Reductase
Internal medicine
medicine
Humans
Genetic Predisposition to Disease
030304 developmental biology
Genetic association
OLDER PATIENTS
Whites
business.industry
HUMAN-LEUKOCYTE ANTIGEN
Reproducibility of Results
Cancer
General Chemistry
Settore MED/15
medicine.disease
IMMUNE ESCAPE
Risk factors
Case-Control Studies
3111 Biomedicine
business
Genome-Wide Association Study
Zdroj: Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
Nat. Commun. 12:6233 (2021)
Nature Communications
ISSN: 2041-1723
Popis: Acute myeloid leukemia (AML) is a hematological malignancy with an undefined heritable risk. Here we perform a meta-analysis of three genome-wide association studies, with replication in a fourth study, incorporating a total of 4018 AML cases and 10488 controls. We identify a genome-wide significant risk locus for AML at 11q13.2 (rs4930561; P = 2.15 × 10−8; KMT5B). We also identify a genome-wide significant risk locus for the cytogenetically normal AML sub-group (N = 1287) at 6p21.32 (rs3916765; P = 1.51 × 10−10; HLA). Our results inform on AML etiology and identify putative functional genes operating in histone methylation (KMT5B) and immune function (HLA).
Genome wide association studies in cancer are used to understand the heritable genetic contribution to disease risk. Here, the authors perform a genome wide association study in European patients with acute myeloid leukemia and identify loci associated with risk of developing the disease.
Databáze: OpenAIRE
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