Structure–activity relationship on the human EP3 prostanoid receptor by use of solid-support chemistry

Autor:	Marie-Claude Carrière, Yves Gareau, Nathalie Tremblay, Helene Juteau, Sonia Lamontagne, Danielle Denis, Marc Labelle, Kathleen M. Metters, Nicole Sawyer
Rok vydání:	2001
Předmět:	Stereochemistry Carboxylic acid Clinical Biochemistry Pharmaceutical Science Ligands Biochemistry Chemical synthesis Cinnamic acid Structure-Activity Relationship chemistry.chemical_compound Suzuki reaction Drug Discovery Combinatorial Chemistry Techniques Humans Receptors Prostaglandin E Cinnamates Structure–activity relationship Molecular Biology chemistry.chemical_classification Molecular Structure Ligand Organic Chemistry Combinatorial chemistry chemistry Benzyl bromide Receptors Prostaglandin E EP3 Subtype Molecular Medicine
Zdroj:	Bioorganic & Medicinal Chemistry Letters. 11:747-749
ISSN:	0960-894X
Popis:	Potent and selective EP3 receptor ligands were found by making a library using solid-support chemistry. These compounds can be obtained by a Suzuki coupling reaction of a solid-supported benzyl bromide using various boronic acids. The yields obtained for this reaction were in the range of 24-95% of arylmethyl cinnamic acid 1 after cleavage from the Wang resin.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66d9c2abc986bb1ec082665781d35603 https://doi.org/10.1016/s0960-894x(01)00056-7 Zobrazit plný text záznamu Full Text from ScienceDirect