Voriconazole Concentrations in the Cerebrospinal Fluid and Brain Tissue of Guinea Pigs and Immunocompromised Patients
| Autor: | Irja Lutsar, S. J. Roffey, Peter F. Troke |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Adult
Male Microbiology (medical) medicine.medical_specialty Pathology Antifungal Agents Adolescent Guinea Pigs Administration Oral Caviidae Gastroenterology Drug Administration Schedule Guinea pig Immunocompromised Host Cerebrospinal fluid Pharmacokinetics Internal medicine Blood plasma medicine Animals Humans Child Mycosis Brain Chemistry Voriconazole biology business.industry Brain Middle Aged Triazoles medicine.disease biology.organism_classification Pyrimidines Infectious Diseases Mycoses Child Preschool Female business Meningitis medicine.drug |
| Zdroj: | Clinical Infectious Diseases. 37:728-732 |
| ISSN: | 1537-6591 1058-4838 |
| DOI: | 10.1086/377131 |
| Popis: | We characterized voriconazole concentrations in the cerebrospinal fluid (CSF) of immunocompetent guinea pigs and patients with invasive fungal infections. In animals, after receipt of oral doses of 4 or 10 mg/kg every 8 h, the mean ratios of CSF to plasma total and free drug concentration were 0.68 and 1.3, respectively. In humans, 1-10 h after receipt of voriconazole, the CSF concentrations ranged from 0.08 to 3.93 microg/mL, and the ratio of CSF to plasma concentration ranged from 0.22 to 1.0 (median, 0.46). |
| Databáze: | OpenAIRE |
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